Matches in SemOpenAlex for { <https://semopenalex.org/work/W2475293453> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2475293453 endingPage "L424" @default.
- W2475293453 startingPage "L419" @default.
- W2475293453 abstract "A rebound phenomenon (severe arterial desaturation and pulmonary vasoconstriction) has been observed in some patients with pulmonary hypertension after sudden discontinuation of nitric oxide (NO) inhalation therapy. The mechanism responsible for this phenomenon is unknown. It has recently been reported that NO synthase (NOS) can be inhibited by NO as a negative feedback mechanism. We therefore hypothesized that this rebound phenomenon might be attributable to reduced endogenous NO production due to inhibition of pulmonary endothelial NOS (eNOS) activity by inhaled NO. To test this hypothesis, vasoreactivities were compared in isolated perfused lungs from rats exposed to 40 ppm NO gas and room air for 2 days. The pressor responses to angiotensin II and hypoxia of lungs from rats exposed to NO were markedly potentiated and their depressor response to bradykinin was considerably impaired, whereas that to sodium nitroprusside was preserved, compared with the responses of those exposed to room air. This altered pulmonary vasoreactivity was also induced by lower concentrations of inhaled NO (as low as 1 ppm) and was completely reversed by discontinuation of NO inhalation for several (< 8) hours. The expression of eNOS mRNA by lungs isolated from rats exposed to 40 ppm NO and room air for 2 days did not differ. These results suggest that pulmonary endogenous NO production is reversibly reduced after relatively short-term NO inhalation, which probably inhibits eNOS activity directly. We speculate that reduced production of pulmonary endogenous NO by exogenous (inhaled) NO could be the mechanism responsible for this rebound phenomenon." @default.
- W2475293453 created "2016-07-22" @default.
- W2475293453 creator A5001107247 @default.
- W2475293453 creator A5004620947 @default.
- W2475293453 creator A5019870531 @default.
- W2475293453 creator A5025010496 @default.
- W2475293453 creator A5050459313 @default.
- W2475293453 creator A5052488928 @default.
- W2475293453 creator A5074673519 @default.
- W2475293453 date "1996-09-01" @default.
- W2475293453 modified "2023-09-25" @default.
- W2475293453 title "Altered vasoreactivity in lungs isolated from rats exposed to nitric oxide gas" @default.
- W2475293453 doi "https://doi.org/10.1152/ajplung.1996.271.3.l419" @default.
- W2475293453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8843790" @default.
- W2475293453 hasPublicationYear "1996" @default.
- W2475293453 type Work @default.
- W2475293453 sameAs 2475293453 @default.
- W2475293453 citedByCount "18" @default.
- W2475293453 countsByYear W24752934532013 @default.
- W2475293453 countsByYear W24752934532015 @default.
- W2475293453 countsByYear W24752934532017 @default.
- W2475293453 countsByYear W24752934532021 @default.
- W2475293453 countsByYear W24752934532022 @default.
- W2475293453 crossrefType "journal-article" @default.
- W2475293453 hasAuthorship W2475293453A5001107247 @default.
- W2475293453 hasAuthorship W2475293453A5004620947 @default.
- W2475293453 hasAuthorship W2475293453A5019870531 @default.
- W2475293453 hasAuthorship W2475293453A5025010496 @default.
- W2475293453 hasAuthorship W2475293453A5050459313 @default.
- W2475293453 hasAuthorship W2475293453A5052488928 @default.
- W2475293453 hasAuthorship W2475293453A5074673519 @default.
- W2475293453 hasConcept C126322002 @default.
- W2475293453 hasConcept C134018914 @default.
- W2475293453 hasConcept C16613235 @default.
- W2475293453 hasConcept C170493617 @default.
- W2475293453 hasConcept C178790620 @default.
- W2475293453 hasConcept C185592680 @default.
- W2475293453 hasConcept C2776954882 @default.
- W2475293453 hasConcept C2777622882 @default.
- W2475293453 hasConcept C2777714996 @default.
- W2475293453 hasConcept C2778326061 @default.
- W2475293453 hasConcept C2779591629 @default.
- W2475293453 hasConcept C2779610285 @default.
- W2475293453 hasConcept C2780930700 @default.
- W2475293453 hasConcept C29323129 @default.
- W2475293453 hasConcept C42219234 @default.
- W2475293453 hasConcept C519581460 @default.
- W2475293453 hasConcept C540031477 @default.
- W2475293453 hasConcept C71924100 @default.
- W2475293453 hasConcept C7836513 @default.
- W2475293453 hasConcept C98274493 @default.
- W2475293453 hasConceptScore W2475293453C126322002 @default.
- W2475293453 hasConceptScore W2475293453C134018914 @default.
- W2475293453 hasConceptScore W2475293453C16613235 @default.
- W2475293453 hasConceptScore W2475293453C170493617 @default.
- W2475293453 hasConceptScore W2475293453C178790620 @default.
- W2475293453 hasConceptScore W2475293453C185592680 @default.
- W2475293453 hasConceptScore W2475293453C2776954882 @default.
- W2475293453 hasConceptScore W2475293453C2777622882 @default.
- W2475293453 hasConceptScore W2475293453C2777714996 @default.
- W2475293453 hasConceptScore W2475293453C2778326061 @default.
- W2475293453 hasConceptScore W2475293453C2779591629 @default.
- W2475293453 hasConceptScore W2475293453C2779610285 @default.
- W2475293453 hasConceptScore W2475293453C2780930700 @default.
- W2475293453 hasConceptScore W2475293453C29323129 @default.
- W2475293453 hasConceptScore W2475293453C42219234 @default.
- W2475293453 hasConceptScore W2475293453C519581460 @default.
- W2475293453 hasConceptScore W2475293453C540031477 @default.
- W2475293453 hasConceptScore W2475293453C71924100 @default.
- W2475293453 hasConceptScore W2475293453C7836513 @default.
- W2475293453 hasConceptScore W2475293453C98274493 @default.
- W2475293453 hasIssue "3" @default.
- W2475293453 hasLocation W24752934531 @default.
- W2475293453 hasLocation W24752934532 @default.
- W2475293453 hasOpenAccess W2475293453 @default.
- W2475293453 hasPrimaryLocation W24752934531 @default.
- W2475293453 hasRelatedWork W2096807231 @default.
- W2475293453 hasRelatedWork W2099366831 @default.
- W2475293453 hasRelatedWork W2163054548 @default.
- W2475293453 hasRelatedWork W2337423144 @default.
- W2475293453 hasRelatedWork W2351037634 @default.
- W2475293453 hasRelatedWork W2389576412 @default.
- W2475293453 hasRelatedWork W2394313808 @default.
- W2475293453 hasRelatedWork W2475293453 @default.
- W2475293453 hasRelatedWork W2766788308 @default.
- W2475293453 hasRelatedWork W2794382739 @default.
- W2475293453 hasVolume "271" @default.
- W2475293453 isParatext "false" @default.
- W2475293453 isRetracted "false" @default.
- W2475293453 magId "2475293453" @default.
- W2475293453 workType "article" @default.