Matches in SemOpenAlex for { <https://semopenalex.org/work/W2475379175> ?p ?o ?g. }
- W2475379175 endingPage "2089" @default.
- W2475379175 startingPage "2081" @default.
- W2475379175 abstract "Knowledge on how changing risk factors influence the progression of albuminuria over time is still limited. Furthermore, large population-based cohorts are needed to study the association between albuminuria change and mortality risk in nondiabetic study participants.We evaluated changes of albuminuria in 6282 nondiabetic individuals from the Norwegian population-based Nord-Trøndelag Health study. Using three albumin/creatinine ratios (ACR), we studied the influence of cardiovascular risk factors on ACR change from baseline to follow-up 11 years later. We evaluated the next 8-year mortality risk by using flexible parametric methods to identify nonlinear main effects and their two-way interactions.Mean albuminuria increased significantly over 11 years (1.82-3.02 mg/mmol, P < 0.0001), but two-thirds of individuals had stable levels (ΔACR -1.40 to 1.40 mg/mmol). Higher age, ACR, and SBP as well as smoking and lower glomerular filtration rate at baseline were associated with increasing albuminuria. Study participants in the upper quartile of the increasing group had mean adjusted hazard ratio 1.31 (P = 0.004) for all-cause mortality compared with those with stable ACR. Those with decreasing ACR also had increased mortality, but the risk was strongly attenuated when adjusting for comorbidity. It also decreased the first 3 years before increasing. There was a strong interaction between baseline ACR and ΔACR. Increasing albuminuria had strongest effect on mortality in study participants with moderately increased baseline values.Both increasing and decreasing albuminuria are significant independent predictors of mortality in nondiabetic individuals, but must be interpreted in light of baseline values. Cutoffs and clinical usefulness in nondiabetic study participants should be further investigated." @default.
- W2475379175 created "2016-08-23" @default.
- W2475379175 creator A5008867854 @default.
- W2475379175 creator A5009154465 @default.
- W2475379175 creator A5046971861 @default.
- W2475379175 date "2016-10-01" @default.
- W2475379175 modified "2023-10-16" @default.
- W2475379175 title "Long-term changes in albuminuria" @default.
- W2475379175 cites W184677336 @default.
- W2475379175 cites W1945685354 @default.
- W2475379175 cites W1971823413 @default.
- W2475379175 cites W1976520486 @default.
- W2475379175 cites W1981562718 @default.
- W2475379175 cites W1982370080 @default.
- W2475379175 cites W1983636771 @default.
- W2475379175 cites W1992089240 @default.
- W2475379175 cites W2003825841 @default.
- W2475379175 cites W2005184654 @default.
- W2475379175 cites W2010579221 @default.
- W2475379175 cites W2022532550 @default.
- W2475379175 cites W2028324384 @default.
- W2475379175 cites W2030049553 @default.
- W2475379175 cites W2031497862 @default.
- W2475379175 cites W2031537135 @default.
- W2475379175 cites W2042318705 @default.
- W2475379175 cites W2054030775 @default.
- W2475379175 cites W2061699759 @default.
- W2475379175 cites W2065920514 @default.
- W2475379175 cites W2065974896 @default.
- W2475379175 cites W2081231656 @default.
- W2475379175 cites W2089034838 @default.
- W2475379175 cites W2089082626 @default.
- W2475379175 cites W2091026860 @default.
- W2475379175 cites W2098531157 @default.
- W2475379175 cites W2099628040 @default.
- W2475379175 cites W2102266871 @default.
- W2475379175 cites W2107031719 @default.
- W2475379175 cites W2119248404 @default.
- W2475379175 cites W2119313387 @default.
- W2475379175 cites W2123831918 @default.
- W2475379175 cites W2125089162 @default.
- W2475379175 cites W2127975399 @default.
- W2475379175 cites W2135255861 @default.
- W2475379175 cites W2136106925 @default.
- W2475379175 cites W2139968474 @default.
- W2475379175 cites W2146571866 @default.
- W2475379175 cites W2155336724 @default.
- W2475379175 cites W2156822292 @default.
- W2475379175 cites W2162553931 @default.
- W2475379175 cites W2162772535 @default.
- W2475379175 cites W2163673475 @default.
- W2475379175 cites W2163914595 @default.
- W2475379175 cites W2165713489 @default.
- W2475379175 cites W2328569797 @default.
- W2475379175 doi "https://doi.org/10.1097/hjh.0000000000001035" @default.
- W2475379175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27442788" @default.
- W2475379175 hasPublicationYear "2016" @default.
- W2475379175 type Work @default.
- W2475379175 sameAs 2475379175 @default.
- W2475379175 citedByCount "4" @default.
- W2475379175 countsByYear W24753791752016 @default.
- W2475379175 countsByYear W24753791752017 @default.
- W2475379175 countsByYear W24753791752022 @default.
- W2475379175 crossrefType "journal-article" @default.
- W2475379175 hasAuthorship W2475379175A5008867854 @default.
- W2475379175 hasAuthorship W2475379175A5009154465 @default.
- W2475379175 hasAuthorship W2475379175A5046971861 @default.
- W2475379175 hasConcept C126322002 @default.
- W2475379175 hasConcept C159641895 @default.
- W2475379175 hasConcept C207103383 @default.
- W2475379175 hasConcept C2776174234 @default.
- W2475379175 hasConcept C2780306776 @default.
- W2475379175 hasConcept C2908647359 @default.
- W2475379175 hasConcept C44249647 @default.
- W2475379175 hasConcept C50382708 @default.
- W2475379175 hasConcept C68443243 @default.
- W2475379175 hasConcept C71924100 @default.
- W2475379175 hasConcept C99454951 @default.
- W2475379175 hasConceptScore W2475379175C126322002 @default.
- W2475379175 hasConceptScore W2475379175C159641895 @default.
- W2475379175 hasConceptScore W2475379175C207103383 @default.
- W2475379175 hasConceptScore W2475379175C2776174234 @default.
- W2475379175 hasConceptScore W2475379175C2780306776 @default.
- W2475379175 hasConceptScore W2475379175C2908647359 @default.
- W2475379175 hasConceptScore W2475379175C44249647 @default.
- W2475379175 hasConceptScore W2475379175C50382708 @default.
- W2475379175 hasConceptScore W2475379175C68443243 @default.
- W2475379175 hasConceptScore W2475379175C71924100 @default.
- W2475379175 hasConceptScore W2475379175C99454951 @default.
- W2475379175 hasIssue "10" @default.
- W2475379175 hasLocation W24753791751 @default.
- W2475379175 hasLocation W24753791752 @default.
- W2475379175 hasOpenAccess W2475379175 @default.
- W2475379175 hasPrimaryLocation W24753791751 @default.
- W2475379175 hasRelatedWork W2003939174 @default.
- W2475379175 hasRelatedWork W2057842953 @default.
- W2475379175 hasRelatedWork W2113389249 @default.
- W2475379175 hasRelatedWork W2144649651 @default.