Matches in SemOpenAlex for { <https://semopenalex.org/work/W2475667023> ?p ?o ?g. }
- W2475667023 endingPage "158" @default.
- W2475667023 startingPage "152" @default.
- W2475667023 abstract "We review the current clinical knowledge surrounding one of the most promising immune checkpoint pathways currently investigated in head and neck squamous cell carcinoma patients, programmed cell death-1 (PD-1) and its ligands (PD-L1 and PD-L2). We review ongoing clinical trials and associated clinical responses observed with targeting the receptor, PD-1, and its ligand, PD-L1. A recent phase III clinical trial (Checkmate 141) demonstrated an improved overall survival in head and neck cancer patients treated with anti-PD-1 monotherapy as compared to standard of care for recurrent and/or metastatic disease, which raises questions on how best to incorporate immunotherapy in the context of standard of care. We discuss biomarkers of response to this class of novel drugs, which is an area of active investigation. Lastly, we project future directions in the field wherein understanding how the Fc portions of the various monoclonal antibodies may impact their clinical efficacy as well as discuss areas where our next advances may take place, such as combination strategies." @default.
- W2475667023 created "2016-08-23" @default.
- W2475667023 creator A5028801725 @default.
- W2475667023 creator A5032809504 @default.
- W2475667023 creator A5063313488 @default.
- W2475667023 date "2016-10-01" @default.
- W2475667023 modified "2023-10-17" @default.
- W2475667023 title "The role of antagonists of the PD-1:PD-L1/PD-L2 axis in head and neck cancer treatment" @default.
- W2475667023 cites W1568317937 @default.
- W2475667023 cites W1574545886 @default.
- W2475667023 cites W1600211602 @default.
- W2475667023 cites W1601679057 @default.
- W2475667023 cites W1734926275 @default.
- W2475667023 cites W1940241680 @default.
- W2475667023 cites W1950618346 @default.
- W2475667023 cites W1972882573 @default.
- W2475667023 cites W1976269164 @default.
- W2475667023 cites W1977523238 @default.
- W2475667023 cites W1978436252 @default.
- W2475667023 cites W1984545852 @default.
- W2475667023 cites W1986899796 @default.
- W2475667023 cites W1989270381 @default.
- W2475667023 cites W1990779902 @default.
- W2475667023 cites W1996891899 @default.
- W2475667023 cites W2002861511 @default.
- W2475667023 cites W2009720434 @default.
- W2475667023 cites W2010121426 @default.
- W2475667023 cites W2014116920 @default.
- W2475667023 cites W2016983859 @default.
- W2475667023 cites W2017577544 @default.
- W2475667023 cites W2027538916 @default.
- W2475667023 cites W2028376975 @default.
- W2475667023 cites W2035852466 @default.
- W2475667023 cites W2039123767 @default.
- W2475667023 cites W2044224425 @default.
- W2475667023 cites W2045654426 @default.
- W2475667023 cites W2049553585 @default.
- W2475667023 cites W2050999762 @default.
- W2475667023 cites W2052727153 @default.
- W2475667023 cites W2053393698 @default.
- W2475667023 cites W2054563013 @default.
- W2475667023 cites W2054628179 @default.
- W2475667023 cites W2061572018 @default.
- W2475667023 cites W2062029576 @default.
- W2475667023 cites W2066671159 @default.
- W2475667023 cites W2071606440 @default.
- W2475667023 cites W2075819066 @default.
- W2475667023 cites W2083262432 @default.
- W2475667023 cites W2084538615 @default.
- W2475667023 cites W2087013294 @default.
- W2475667023 cites W2087186136 @default.
- W2475667023 cites W2087751238 @default.
- W2475667023 cites W2092233067 @default.
- W2475667023 cites W2095692889 @default.
- W2475667023 cites W2097855813 @default.
- W2475667023 cites W2100117872 @default.
- W2475667023 cites W2101990345 @default.
- W2475667023 cites W2104885590 @default.
- W2475667023 cites W2107752337 @default.
- W2475667023 cites W2112927491 @default.
- W2475667023 cites W2118471749 @default.
- W2475667023 cites W2119146367 @default.
- W2475667023 cites W2130207101 @default.
- W2475667023 cites W2141269240 @default.
- W2475667023 cites W2143680521 @default.
- W2475667023 cites W2145857936 @default.
- W2475667023 cites W2146906100 @default.
- W2475667023 cites W2147567659 @default.
- W2475667023 cites W2147622445 @default.
- W2475667023 cites W2149252678 @default.
- W2475667023 cites W2153560947 @default.
- W2475667023 cites W2155464214 @default.
- W2475667023 cites W2159170430 @default.
- W2475667023 cites W2160834915 @default.
- W2475667023 cites W2291298003 @default.
- W2475667023 cites W2301707196 @default.
- W2475667023 cites W2560367415 @default.
- W2475667023 cites W2626773261 @default.
- W2475667023 cites W2811088815 @default.
- W2475667023 cites W364750170 @default.
- W2475667023 doi "https://doi.org/10.1016/j.oraloncology.2016.08.001" @default.
- W2475667023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5690560" @default.
- W2475667023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27503244" @default.
- W2475667023 hasPublicationYear "2016" @default.
- W2475667023 type Work @default.
- W2475667023 sameAs 2475667023 @default.
- W2475667023 citedByCount "47" @default.
- W2475667023 countsByYear W24756670232016 @default.
- W2475667023 countsByYear W24756670232017 @default.
- W2475667023 countsByYear W24756670232018 @default.
- W2475667023 countsByYear W24756670232019 @default.
- W2475667023 countsByYear W24756670232020 @default.
- W2475667023 countsByYear W24756670232021 @default.
- W2475667023 countsByYear W24756670232022 @default.
- W2475667023 countsByYear W24756670232023 @default.
- W2475667023 crossrefType "journal-article" @default.
- W2475667023 hasAuthorship W2475667023A5028801725 @default.
- W2475667023 hasAuthorship W2475667023A5032809504 @default.