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- W2475701158 abstract "Background: Chronic airway inflammation in children with cystic fibrosis (CF) starts early in life, leading to progressive structural lung disease. Recent metabolomics studies suggest that they can reveal insight into pathways relevant to early CF airways disease and can be measured non-invasively using an exhaled breath condensate. Methods: Metabolites previously associated with airway inflammation were measured via mass spectrometry on supernatants of bronchoalveolar lavage (BAL) from 34 preschool children enrolled in AREST CF who underwent chest CT and BAL from two lobes during 42 visits (n=84). Ordinal logistic regression models were fitted using lobe specific CT scores as an outcome categorized as presence or absence of bronchiectasis and presence of bronchial wall thickening as an intermediate step in disease severity. Models were adjusted for gender and were assessed with and without neutrophils. Results: Decreased levels of adenosine and its metabolite inosine were found in more diseased lobes with odds ratios (OR) of 0.32 (0.18, 0.59; p Conclusions: The data provides new insight into adenosine signaling pathways involved in airway inflammatory responses and has identified a number of metabolites associated with early disease that can potentially serve as non-invasive biomarkers and therapeutic targets in early CF." @default.
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- W2475701158 date "2015-09-01" @default.
- W2475701158 modified "2023-09-24" @default.
- W2475701158 title "Association between lobe specific bronchoalveolar lavage fluid metabolites and structural lung disease in young children with cystic fibrosis" @default.
- W2475701158 doi "https://doi.org/10.1183/13993003.congress-2015.pa2055" @default.
- W2475701158 hasPublicationYear "2015" @default.
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