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- W2475710367 abstract "Binding studies of copper(I) complexes of two phenanthrolines, dmp (2,9-dimethyl-1,10-phenanthroline) and bcp (2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline), with DNA are described. The presence of the methyl substituents in the 2 and 9 positions allows us to focus on DNA binding because the reduction potential of the copper is too positive for significant nuclease activity. The results are consistent with simple surface association of Cu(dmp)2+, presumably at the minor groove of DNA, and with intercalation of Cu(bcp)2+ via the major groove. In the course of this investigation we have relied on the techniques of visible absorption spectroscopy and electrophoresis, as well as luminescence spectroscopy in the case of Cu(bcp)2+. The luminescence results show that DNA forms a relatively rigid adduct with the bcp complex because solvent-induced quenching of the charge-transfer excited state-normally a very efficient process-is suppressed. Although Cu(dmp)2+ and Cu(bcp)2+ show negligible nucleolytic activity, these studies are relevant to the binding interactions of simple phenanthroline complexes that have been found to function as efficient, broad-spectrum artificial nucleases and useful probes of DNA structures (Sigman, D. S. Acc. Chem. Res. 1986, 19, 180—186)." @default.
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- W2475710367 date "1989-08-10" @default.
- W2475710367 modified "2023-10-18" @default.
- W2475710367 title "Excited-State Modalities for Studying the Binding of Copper Phenanthrolines to DNA" @default.
- W2475710367 doi "https://doi.org/10.1021/bk-1989-0402.ch003" @default.
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