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• W2475746120 abstract "The role of symmetric division in stem cell biology is ambiguous. It is necessary after injuries, but if symmetric divisions occur too often, the appearance of tumours is more likely. To explore the role of symmetric and asymmetric division in cell populations, we propose a mathematical model of competition of populations, in which the stem cell expansion is controlled by fully differentiated cells. We show that there is an optimal fraction of symmetric stem cell division, which maximises the long-term survival probability of the organism. Moreover, we show the optimal number of stem cells in a tissue, and we show that number has to be small enough to reduce the probability of the appearance of advantageous malignant cells, and large enough to assure that the population will not be suppressed by stochastic fluctuations." @default.
• W2475746120 created "2016-08-23" @default.
• W2475746120 creator A5002653053 @default.
• W2475746120 date "2016-10-01" @default.
• W2475746120 modified "2023-09-27" @default.
• W2475746120 title "Optimal architecture of differentiation cascades with asymmetric and symmetric stem cell division" @default.
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• W2475746120 doi "https://doi.org/10.1016/j.jtbi.2016.07.029" @default.
• W2475746120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27452530" @default.
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