Matches in SemOpenAlex for { <https://semopenalex.org/work/W2475749950> ?p ?o ?g. }
- W2475749950 abstract "Cell cycle control by trophic factors has a key role in regulation of cell proliferation in all organisms. Nutrients are one of these important factors needed by cells to reproduce, so very well regulated mechanisms must exist that connect nutrient availability to cell cycle. Hence the importance on studying how exactly nutrient-dependent signaling pathways work. Cln3, the most upstream G1 cyclin in Saccharomyces cerevisiae, is one well demonstrated common effector of multiple nutrient-dependent signaling pathways. Moreover, its role in cell cycle is crucial. So it is a good candidate to regulate cell cycle progression in response to nutrient availability. One important question is to find the protein that could directly modulate Cln3 levels in response to nutrient availability. This protein could play as a nutrient sensor and as a cell cycle regulator at the same time. In the present thesis, Pho85 is founded to be the protein that could run these two highly different tasks, because of its well-characterized properties on sensing phosphate availability and the well-known functions on modulating cell cycle as CDK. The results of the present work clearly demonstrate that when phosphate is present, Pho85 regulates Cln3 levels by increasing the stability of the cyclin through specific phosphorylations, promoting cell cycle progression. Contrary, under phosphate depletion conditions, Pho85 become inactive and Cln3 is rapidly degraded, leading to a cell cycle arrest in order to maintain cell chronological lifespan." @default.
- W2475749950 created "2016-08-23" @default.
- W2475749950 creator A5025930545 @default.
- W2475749950 date "2012-09-21" @default.
- W2475749950 modified "2023-09-23" @default.
- W2475749950 title "Nutrient availability regulates cell cycle through a Pho85 CDK-dependent control of Cln3 cyclin stability" @default.
- W2475749950 cites W103106915 @default.
- W2475749950 cites W15212789 @default.
- W2475749950 cites W1521764524 @default.
- W2475749950 cites W1539988911 @default.
- W2475749950 cites W1547033864 @default.
- W2475749950 cites W1576917357 @default.
- W2475749950 cites W1590458072 @default.
- W2475749950 cites W1631725776 @default.
- W2475749950 cites W1638194466 @default.
- W2475749950 cites W1650504959 @default.
- W2475749950 cites W169216998 @default.
- W2475749950 cites W1759539608 @default.
- W2475749950 cites W1778463151 @default.
- W2475749950 cites W1813812686 @default.
- W2475749950 cites W1831912214 @default.
- W2475749950 cites W1838616807 @default.
- W2475749950 cites W1893234428 @default.
- W2475749950 cites W1909120931 @default.
- W2475749950 cites W1929688237 @default.
- W2475749950 cites W1943809043 @default.
- W2475749950 cites W1955808217 @default.
- W2475749950 cites W1964257510 @default.
- W2475749950 cites W1967724361 @default.
- W2475749950 cites W1970188754 @default.
- W2475749950 cites W1970783685 @default.
- W2475749950 cites W1971353345 @default.
- W2475749950 cites W1971637500 @default.
- W2475749950 cites W1975139474 @default.
- W2475749950 cites W1976086369 @default.
- W2475749950 cites W1976106501 @default.
- W2475749950 cites W1976953376 @default.
- W2475749950 cites W1977880141 @default.
- W2475749950 cites W1978217568 @default.
- W2475749950 cites W1979213543 @default.
- W2475749950 cites W1979246102 @default.
- W2475749950 cites W1980585800 @default.
- W2475749950 cites W1981249926 @default.
- W2475749950 cites W1981607001 @default.
- W2475749950 cites W1982290796 @default.
- W2475749950 cites W1983416626 @default.
- W2475749950 cites W1986627314 @default.
- W2475749950 cites W1986707765 @default.
- W2475749950 cites W1987113727 @default.
- W2475749950 cites W1987339939 @default.
- W2475749950 cites W1993366229 @default.
- W2475749950 cites W1994473731 @default.
- W2475749950 cites W1994478080 @default.
- W2475749950 cites W1995011897 @default.
- W2475749950 cites W1996965660 @default.
- W2475749950 cites W1997941087 @default.
- W2475749950 cites W2000309611 @default.
- W2475749950 cites W2001142811 @default.
- W2475749950 cites W2001994073 @default.
- W2475749950 cites W2003698297 @default.
- W2475749950 cites W2004596644 @default.
- W2475749950 cites W2005222967 @default.
- W2475749950 cites W2008486131 @default.
- W2475749950 cites W2012665233 @default.
- W2475749950 cites W2014575814 @default.
- W2475749950 cites W2014789884 @default.
- W2475749950 cites W2015038174 @default.
- W2475749950 cites W2018666541 @default.
- W2475749950 cites W2019557118 @default.
- W2475749950 cites W2025011614 @default.
- W2475749950 cites W2026882865 @default.
- W2475749950 cites W2028193779 @default.
- W2475749950 cites W2028403255 @default.
- W2475749950 cites W2028403872 @default.
- W2475749950 cites W2029361184 @default.
- W2475749950 cites W2029910909 @default.
- W2475749950 cites W2033141310 @default.
- W2475749950 cites W2034162523 @default.
- W2475749950 cites W2035550044 @default.
- W2475749950 cites W2042110657 @default.
- W2475749950 cites W2044413883 @default.
- W2475749950 cites W2044593393 @default.
- W2475749950 cites W2047373064 @default.
- W2475749950 cites W2047746661 @default.
- W2475749950 cites W2048671957 @default.
- W2475749950 cites W2048899019 @default.
- W2475749950 cites W2049366728 @default.
- W2475749950 cites W2049961020 @default.
- W2475749950 cites W2050400409 @default.
- W2475749950 cites W2050416286 @default.
- W2475749950 cites W2053471076 @default.
- W2475749950 cites W2057594508 @default.
- W2475749950 cites W2057811505 @default.
- W2475749950 cites W2060821036 @default.
- W2475749950 cites W2063013559 @default.
- W2475749950 cites W2064249717 @default.
- W2475749950 cites W2064638523 @default.
- W2475749950 cites W2067346106 @default.
- W2475749950 cites W2067735942 @default.
- W2475749950 cites W2068413127 @default.