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• W2475803647 abstract "Improving insulin delivery to patients suffering from insulin-dependent diabetes (IDD) holds significant promise for reducing long-term complications and improving the quality of life of diabetics. The methods being pursued include minimally invasive or noninvasive glucose sensors, which facilitate measurements of blood glucose levels and help improve compliance; development of artificial pancreas systems comprised of a continuous glucose monitor, an insulin infusion pump, and a controller/control algorithm in a closed-loop configuration, which may deliver the appropriate amount of insulin with little attendance from the patient; and therapies based on implantation of living insulin-secreting cells or of tissue substitutes containing such cells. The latter may be considered as the next-generation therapies for diabetics, but require advancements in critical technologies before they are brought to the clinic. Cells that may be used include pancreatic islets, engineered non-β pancreatic cells, cells from the differentiation of stem or progenitor cells, or even  cell lines. Different cell types pose different challenges, ranging from engineering immune acceptance to ensuring expression of sufficient levels of insulin and of insulin secretion in response to glucose. This article critically reviews the current state and future challenges of artificial pancreas and of the cell- and tissue-based therapies for IDD." @default.
• W2475803647 created "2016-08-23" @default.
• W2475803647 creator A5049533278 @default.
• W2475803647 date "2011-01-01" @default.
• W2475803647 modified "2023-09-24" @default.
• W2475803647 title "Artificial Organs | Pancreas" @default.
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