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- W2475883958 abstract "The transmitter substance released from a presynaptic terminal diffuses across the synaptic cleft and acts on the postsynaptic cell. A receptor specialized for the transmitter on the postsynaptic cell membrane is thus the site for interaction between the two excitable cells. Langley (1909) pioneered the concept of receptors for chemical mediators. He found that the contraction of skeletal muscle induced by applying nicotine can be blocked by curare; moreover, the sensitivity to nicotine proved higher at the nerve entry zone than in other regions of the muscle. He also noted that this nicotine sensitivity is preserved even after denervation of the muscle. Langley postulated that the innervation site of muscle fibres must have a ‘receptive substance’ that specifically binds both nicotine and curare. Langley wanted to know where the receptive substance was located. He expected it to be in the cytoplasm, rather than on the membrane, of skeletal muscle." @default.
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- W2475883958 date "1994-12-08" @default.
- W2475883958 modified "2023-09-27" @default.
- W2475883958 title "Historical perspective of the synapse" @default.
- W2475883958 doi "https://doi.org/10.1093/acprof:oso/9780198546870.003.0009" @default.
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