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• W2475960051 abstract "Within immunocompromised populations, the JC polyomavirus is the cause of the often-fatal disease Progressive Multifocal Leukoencephalopathy (PML). JC virus encodes a protein, termed T-antigen (T-ag), which is essential for its replication and pathogenicity. Previous studies of JCV T-ag have, in general, used antibodies raised against SV40 T-ag. Unfortunately, SV40 T-ag is also detected in humans and therefore there have been concerns about cross-reactivity. To address this issue, we have isolated a monoclonal antibody that binds to the JCV, but not the SV40, T-ag origin-binding domain (OBD). Furthermore, the region on the surface of the JCV T-ag OBD that is recognized by the anti-JCV OBD mAb has been mapped. We also demonstrate that the anti-JCV OBD mAb will be a useful reagent for standard techniques (e.g., Westerns blots and ELISAs). Finally, we note that additional monoclonal Abs that are specific for the T-ags encoded by the other human polyomaviruses could be generated by adopting the approach described herein." @default.
• W2475960051 created "2016-08-23" @default.
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• W2475960051 date "2016-10-01" @default.
• W2475960051 modified "2023-10-12" @default.
• W2475960051 title "Isolation of a monoclonal antibody that recognizes the origin binding domain of JCV, but not SV40, large T-antigen" @default.
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• W2475960051 doi "https://doi.org/10.1016/j.virol.2016.07.006" @default.
• W2475960051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27433780" @default.
• W2475960051 hasPublicationYear "2016" @default.
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