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• W2476005103 abstract "Women are twice as likely to suffer from depression as men, yet stress and depression research has relied primarily on the responses of males. Early life stress is hypothesized to influence the development of vulnerability to depression while adult stress exposure can act as a trigger in those predisposed. This relationship is mediated by other environmental factors. Maternal care and the social environment appear to be particularly important for mammals. The purpose of this thesis was twofold: to develop an animal model of depression for use in female rats based on the chronic mild stress (CMS) model previously validated for use in male rodents, and to apply this model in female offspring of mothers exposed to physical restraint in the second half of gestation representing an early life insult. Results indicate that a modified CMS model was able to alter hedonic and physiological responses not present in the original model. Housing condition interacted with CMS in that effects were evident only in singly housed rats. While gestational stress (GS) altered maternal weight and behavioural profiles related to offspring care and anxiety, little to no behavioural effects were noted in juvenile or adult offspring. Applying the modified CMS model to adult female offspring resulted in an anhedonic-like response that recovered rapidly prior to the third week of CMS. Weight in GS female rats was attenuated throughout life beginning post weaning. When taken together, these results demonstrate that stress-based models, previously established in males, must be altered to accommodate the hormonally intact female rat in two ways: first, to eliminate extraneous variables that may interfere with the estrous cycle and mask possible stress effects, and secondly, to consider the appropriateness of individual stressors to induce a stress response in females. While a general lack of" @default.
• W2476005103 created "2016-08-23" @default.
• W2476005103 creator A5072817738 @default.
• W2476005103 date "2011-01-01" @default.
• W2476005103 modified "2023-09-24" @default.
• W2476005103 title "Modeling depression in the rat: the development and usefulness of a female-centric approach" @default.
• W2476005103 cites W13893899 @default.
• W2476005103 cites W1502880414 @default.
• W2476005103 cites W1518574168 @default.
• W2476005103 cites W1519712908 @default.
• W2476005103 cites W1527534059 @default.
• W2476005103 cites W1545854379 @default.
• W2476005103 cites W1547221141 @default.
• W2476005103 cites W1558311959 @default.
• W2476005103 cites W1560037133 @default.
• W2476005103 cites W1562811233 @default.
• W2476005103 cites W1564681163 @default.
• W2476005103 cites W1583327662 @default.
• W2476005103 cites W1583817176 @default.
• W2476005103 cites W1586744782 @default.
• W2476005103 cites W1588195558 @default.
• W2476005103 cites W1695539136 @default.
• W2476005103 cites W1729436097 @default.
• W2476005103 cites W1730717983 @default.
• W2476005103 cites W177639557 @default.
• W2476005103 cites W1906439521 @default.
• W2476005103 cites W1906690582 @default.
• W2476005103 cites W1949208063 @default.
• W2476005103 cites W1961990310 @default.
• W2476005103 cites W1963959378 @default.
• W2476005103 cites W1964748495 @default.
• W2476005103 cites W1965391675 @default.
• W2476005103 cites W1966082006 @default.
• W2476005103 cites W1966171569 @default.
• W2476005103 cites W1966873633 @default.
• W2476005103 cites W1967832563 @default.
• W2476005103 cites W1969885562 @default.
• W2476005103 cites W1970942595 @default.
• W2476005103 cites W1971391910 @default.
• W2476005103 cites W1971576036 @default.
• W2476005103 cites W1971725866 @default.
• W2476005103 cites W1973518997 @default.
• W2476005103 cites W1974782271 @default.
• W2476005103 cites W1975118114 @default.
• W2476005103 cites W1975252975 @default.
• W2476005103 cites W1976062681 @default.
• W2476005103 cites W1976381356 @default.
• W2476005103 cites W1977430165 @default.
• W2476005103 cites W1978338619 @default.
• W2476005103 cites W1980108852 @default.
• W2476005103 cites W1980458726 @default.
• W2476005103 cites W1981337627 @default.
• W2476005103 cites W1981496403 @default.
• W2476005103 cites W1981707861 @default.
• W2476005103 cites W1982594459 @default.
• W2476005103 cites W1983178570 @default.
• W2476005103 cites W1983301769 @default.
• W2476005103 cites W1983922562 @default.
• W2476005103 cites W1984960813 @default.
• W2476005103 cites W1985991621 @default.
• W2476005103 cites W1988135204 @default.
• W2476005103 cites W1990354839 @default.
• W2476005103 cites W1990495766 @default.
• W2476005103 cites W1990613148 @default.
• W2476005103 cites W1992284534 @default.
• W2476005103 cites W1992316325 @default.
• W2476005103 cites W1992674129 @default.
• W2476005103 cites W1993513360 @default.
• W2476005103 cites W1994076014 @default.
• W2476005103 cites W1994716040 @default.
• W2476005103 cites W1996303231 @default.
• W2476005103 cites W1996362121 @default.
• W2476005103 cites W1998185211 @default.
• W2476005103 cites W1998469765 @default.
• W2476005103 cites W1999509305 @default.
• W2476005103 cites W2002378053 @default.
• W2476005103 cites W2002623346 @default.
• W2476005103 cites W2003772211 @default.
• W2476005103 cites W2004424018 @default.
• W2476005103 cites W2004721650 @default.
• W2476005103 cites W2006125298 @default.
• W2476005103 cites W2006555785 @default.
• W2476005103 cites W2006578440 @default.
• W2476005103 cites W2006882279 @default.
• W2476005103 cites W2008221786 @default.
• W2476005103 cites W2010914134 @default.
• W2476005103 cites W2011305202 @default.
• W2476005103 cites W2011375438 @default.
• W2476005103 cites W2011538551 @default.
• W2476005103 cites W2012359887 @default.
• W2476005103 cites W2012981764 @default.
• W2476005103 cites W2013614651 @default.
• W2476005103 cites W2014182497 @default.
• W2476005103 cites W2015288073 @default.
• W2476005103 cites W2016428032 @default.
• W2476005103 cites W2017324858 @default.
• W2476005103 cites W2020026724 @default.
• W2476005103 cites W2020506565 @default.
• W2476005103 cites W2020825343 @default.
• W2476005103 cites W2020894685 @default.

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