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- W2476081844 abstract "Substantial evidence implicates 5-hydroxytryptamine (5-HT) neurones in the control of cardiovascular function. The precise nature of that role remains, however, undefined, a reflection in part of the plurality of 5-HT receptors and, in particular, the absence until recently of truly selective agonists and antagonists for these sites (Bradley et al., 1986). However, a number of compounds are now recognized to have both high affinity and a certain selectivity for the 5-HT1A subtype of high-affinity [3H]-5-HT binding sites, including 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), dipropyl-5-carboxamidotryptamine (DP-5-CT), MDL 72832, ipsapirone and flesinoxan (Middlemiss and Fozard, 1983; Dompert et al., 1985; Hagenbach et al., 1986; Bevan et al., 1986; Fozard et al., 1987a). Described below are the results from experiments in rats and cats in which these compounds have been used to explore the role of the putative 5-HT1Areceptor in cardiovascular control." @default.
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- W2476081844 date "1989-01-01" @default.
- W2476081844 modified "2023-09-23" @default.
- W2476081844 title "5-HT1A Receptors and Cardiovascular Control" @default.
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- W2476081844 doi "https://doi.org/10.1007/978-1-349-10114-6_19" @default.
- W2476081844 hasPublicationYear "1989" @default.
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