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• W2476095243 abstract "ABSTRACT Adrenomedullin 2 (AM2), or intermedin (IMD), is a novel peptide discovered from the comparative genomic approach. In mammals, AM, calcitonin gene-related peptide (CGRP), and amylin are members of the CGRP family. In teleost fish, however, five AMs, named AM1–5, form an independent subfamily. Based on the fish sequence, AM2/IMD was identified in the human, rat, and mouse. AM2/IMD is expressed abundantly in the kidney, digestive tracts, heart, and brain, and it exerts a spectrum of renal, cardiovascular, gastrointestinal, and appetite-related actions either directly or via the central nervous system. AM2/IMD increases intracellular cAMP by binding to calcitonin receptor or calcitonin receptor-like receptor associated with receptor activity-modifying proteins, but another AM2-specific receptor may also exist." @default.
• W2476095243 created "2016-08-23" @default.
• W2476095243 creator A5007801419 @default.
• W2476095243 date "2013-01-01" @default.
• W2476095243 modified "2023-09-25" @default.
• W2476095243 title "Adrenomedullin 2/Intermedin" @default.
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• W2476095243 doi "https://doi.org/10.1016/b978-0-12-385095-9.00198-6" @default.
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