Matches in SemOpenAlex for { <https://semopenalex.org/work/W2476095410> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W2476095410 endingPage "352" @default.
- W2476095410 startingPage "341" @default.
- W2476095410 abstract "A report is given about a program that proposes many-step syntheses for a given organic compound, without interacting with the user after the initial description of the problem. The problem description includes the structure of the desired goal molecule, complete with chirality, the maximum number of steps for an acceptable synthesis and the minimum overall yield required. Optionally, the problem description may also include the specification of acceptable starting materials. These may be specifically stated, or generally indicated, i.e. with a given skeleton. The maximum number of rings, functional groups and chiral centers for an acceptably simple starting material may also be given. An eight step synthesis of the contraceptive Depo-Provera proposed by the program, which starts from progesterone, is presented. A short prostaglandin synthesis, similar to one reported in the literature, was also proposed by the program. Various ways of managing the combinatorial explosion problem were described. Basically we want to maximize the number of building reactions and minimize the number of facilitating reactions. The facilitating reactions should not be suggested unless they actually facilitate a specific building reaction. There must also be an upper limit on the number of sequential facilitating reactions that may be performed without doing any building reactions." @default.
- W2476095410 created "2016-08-23" @default.
- W2476095410 creator A5080702934 @default.
- W2476095410 date "1979-11-28" @default.
- W2476095410 modified "2023-09-26" @default.
- W2476095410 title "Syntheses of Drugs Proposed by a Computer Program" @default.
- W2476095410 doi "https://doi.org/10.1021/bk-1979-0112.ch016" @default.
- W2476095410 hasPublicationYear "1979" @default.
- W2476095410 type Work @default.
- W2476095410 sameAs 2476095410 @default.
- W2476095410 citedByCount "1" @default.
- W2476095410 crossrefType "book-chapter" @default.
- W2476095410 hasAuthorship W2476095410A5080702934 @default.
- W2476095410 hasConcept C111472728 @default.
- W2476095410 hasConcept C126255220 @default.
- W2476095410 hasConcept C134121241 @default.
- W2476095410 hasConcept C138885662 @default.
- W2476095410 hasConcept C185592680 @default.
- W2476095410 hasConcept C191897082 @default.
- W2476095410 hasConcept C192562407 @default.
- W2476095410 hasConcept C21951064 @default.
- W2476095410 hasConcept C2780586882 @default.
- W2476095410 hasConcept C33923547 @default.
- W2476095410 hasConcept C41008148 @default.
- W2476095410 hasConceptScore W2476095410C111472728 @default.
- W2476095410 hasConceptScore W2476095410C126255220 @default.
- W2476095410 hasConceptScore W2476095410C134121241 @default.
- W2476095410 hasConceptScore W2476095410C138885662 @default.
- W2476095410 hasConceptScore W2476095410C185592680 @default.
- W2476095410 hasConceptScore W2476095410C191897082 @default.
- W2476095410 hasConceptScore W2476095410C192562407 @default.
- W2476095410 hasConceptScore W2476095410C21951064 @default.
- W2476095410 hasConceptScore W2476095410C2780586882 @default.
- W2476095410 hasConceptScore W2476095410C33923547 @default.
- W2476095410 hasConceptScore W2476095410C41008148 @default.
- W2476095410 hasLocation W24760954101 @default.
- W2476095410 hasOpenAccess W2476095410 @default.
- W2476095410 hasPrimaryLocation W24760954101 @default.
- W2476095410 hasRelatedWork W1887191277 @default.
- W2476095410 hasRelatedWork W1965976175 @default.
- W2476095410 hasRelatedWork W2018619927 @default.
- W2476095410 hasRelatedWork W2046577163 @default.
- W2476095410 hasRelatedWork W2329865134 @default.
- W2476095410 hasRelatedWork W2334954212 @default.
- W2476095410 hasRelatedWork W2776018879 @default.
- W2476095410 hasRelatedWork W2964285269 @default.
- W2476095410 hasRelatedWork W4235288607 @default.
- W2476095410 hasRelatedWork W4248389398 @default.
- W2476095410 isParatext "false" @default.
- W2476095410 isRetracted "false" @default.
- W2476095410 magId "2476095410" @default.
- W2476095410 workType "book-chapter" @default.