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- W2476129780 endingPage "17" @default.
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- W2476129780 abstract "This chapter discusses the structural analysis of the human Immunoglobulin heavy chain locus. The immunoglobulin (Ig) molecule is composed of heavy (H) and light (L) chains, both of which consist of variable (V) and constant (C) regions. The V region is responsible for antigen binding, whereas the C H region specifies the isotype of Ig. Genes encoding IgH V regions are split in V H , diversity (D H ), and joining (J H ) segments. Each of the three segments is assembled in a functional V H gene by a somatic genetic event called VDJ recombination. The human C H locus comprises 11 C H genes, out of which 2 are pseudogenes. The V H and C H loci are physically linked on the chromosome in the order of 5 '- V H -D H -J H -C H -3'. Evolutionary studies of V H organization, structure, and comparison of V H loci between related species will provide insight to the molecular mechanisms that govern the evolution of multigene families. In response to the rapid evolution of genome sequencing technology, the complete nucleotide sequence of the entire human IgH locus is now available. It provides an enormously beneficial reference to V H gene mapping and polymorphisms with detailed structure of the human C H locus." @default.
- W2476129780 created "2016-08-23" @default.
- W2476129780 creator A5042371436 @default.
- W2476129780 date "2004-01-01" @default.
- W2476129780 modified "2023-10-17" @default.
- W2476129780 title "Human Immunoglobulin Heavy Chain Locus" @default.
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