FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2476157032> ?p ?o ?g. }

• W2476157032 endingPage "1327" @default.
• W2476157032 startingPage "1315" @default.
• W2476157032 abstract "Summary Background Personal exposure to fungal bioaerosols derived from contaminated building materials or agricultural commodities may induce or exacerbate a variety of adverse health effects. The genomic mechanisms that underlie pulmonary immune responses to fungal bioaerosols have remained unclear. Objective The impact of fungal viability on the pulmonary micro RNA and messenger RNA profiles that regulate murine immune responses was evaluated following subchronic inhalation exposure to Aspergillus fumigatus conidia. Methods Three groups of naïve B6C3F1/N mice were exposed via nose‐only inhalation to A. fumigatus viable conidia, heat‐inactivated conidia (HIC), or HEPA ‐filtered air twice a week for 13 weeks. Total RNA was isolated from whole lung 24 and 48 h postfinal exposure and was further processed for gene expression and micro RNA array analysis. The molecular network pathways between viable and HIC groups were evaluated. Results Comparison of data sets revealed increased Il4 , Il13 and Il33 expression in mice exposed to viable vs. HIC. Of 415 micro RNA s detected, approximately 50% were altered in mice exposed to viable vs. HIC 48 h postexposure. Significantly down‐regulated ( P ≤ 0.05) miR‐29a‐3p was predicted to regulate TGF ‐ β 3 and Clec7a , genes involved in innate responses to viable A. fumigatus . Also significantly down‐regulated ( P ≤ 0.05), miR‐23b‐3p regulates genes involved in pulmonary IL ‐13 and IL ‐33 responses and SMAD 2 , downstream of TGF ‐β signalling. Using Ingenuity Pathway Analysis, a novel interaction was identified between viable conidia and SMAD 2/3 . Conclusions and Clinical Relevance Examination of the pulmonary genetic profiles revealed differentially expressed genes and micro RNA s following subchronic inhalation exposure to A. fumigatus . Micro RNA s regulating genes involved in the pulmonary immune responses were those with the greatest fold change. Specifically, germinating A. fumigatus conidia were associated with Clec7a and were predicted to interact with Il13 and Il33 . Furthermore, altered micro RNA s may serve as potential biomarkers to evaluate fungal exposure." @default.
• W2476157032 created "2016-08-23" @default.
• W2476157032 creator A5006246995 @default.
• W2476157032 creator A5015102283 @default.
• W2476157032 creator A5023091621 @default.
• W2476157032 creator A5040813988 @default.
• W2476157032 creator A5042887827 @default.
• W2476157032 creator A5044861199 @default.
• W2476157032 creator A5048099959 @default.
• W2476157032 creator A5052044884 @default.
• W2476157032 date "2016-09-16" @default.
• W2476157032 modified "2023-10-09" @default.
• W2476157032 title "Influence of <i>Aspergillus fumigatus</i> conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure" @default.
• W2476157032 cites W144423133 @default.
• W2476157032 cites W1524549627 @default.
• W2476157032 cites W1526700155 @default.
• W2476157032 cites W1563601154 @default.
• W2476157032 cites W1610765626 @default.
• W2476157032 cites W1833918098 @default.
• W2476157032 cites W1967686561 @default.
• W2476157032 cites W1969453606 @default.
• W2476157032 cites W1971847988 @default.
• W2476157032 cites W1974646727 @default.
• W2476157032 cites W1981835842 @default.
• W2476157032 cites W1991320836 @default.
• W2476157032 cites W1995957006 @default.
• W2476157032 cites W2002938531 @default.
• W2476157032 cites W2003581234 @default.
• W2476157032 cites W2006170617 @default.
• W2476157032 cites W2007031153 @default.
• W2476157032 cites W2009663348 @default.
• W2476157032 cites W2012702774 @default.
• W2476157032 cites W2014119043 @default.
• W2476157032 cites W2017017949 @default.
• W2476157032 cites W2020441471 @default.
• W2476157032 cites W2021215684 @default.
• W2476157032 cites W2021852487 @default.
• W2476157032 cites W2029962149 @default.
• W2476157032 cites W2030177842 @default.
• W2476157032 cites W2035908500 @default.
• W2476157032 cites W2037700057 @default.
• W2476157032 cites W2041414113 @default.
• W2476157032 cites W2043923831 @default.
• W2476157032 cites W2050155729 @default.
• W2476157032 cites W2050444114 @default.
• W2476157032 cites W2051806436 @default.
• W2476157032 cites W2058711543 @default.
• W2476157032 cites W2058906301 @default.
• W2476157032 cites W2059304937 @default.
• W2476157032 cites W2069009920 @default.
• W2476157032 cites W2069640533 @default.
• W2476157032 cites W2075171560 @default.
• W2476157032 cites W2075223145 @default.
• W2476157032 cites W2085177202 @default.
• W2476157032 cites W2088972943 @default.
• W2476157032 cites W2098889528 @default.
• W2476157032 cites W2099176294 @default.
• W2476157032 cites W2101417884 @default.
• W2476157032 cites W2102731598 @default.
• W2476157032 cites W2104610341 @default.
• W2476157032 cites W2105444747 @default.
• W2476157032 cites W2105988030 @default.
• W2476157032 cites W2113093407 @default.
• W2476157032 cites W2113313714 @default.
• W2476157032 cites W2116665225 @default.
• W2476157032 cites W2121691225 @default.
• W2476157032 cites W2121873857 @default.
• W2476157032 cites W2122889851 @default.
• W2476157032 cites W2128097641 @default.
• W2476157032 cites W2129837490 @default.
• W2476157032 cites W2130862272 @default.
• W2476157032 cites W2135810600 @default.
• W2476157032 cites W2152978188 @default.
• W2476157032 cites W2155954232 @default.
• W2476157032 cites W2162074188 @default.
• W2476157032 cites W2166387000 @default.
• W2476157032 cites W2278466995 @default.
• W2476157032 cites W2328224985 @default.
• W2476157032 cites W2796725260 @default.
• W2476157032 cites W4234501173 @default.
• W2476157032 cites W4240510335 @default.
• W2476157032 cites W4360754313 @default.
• W2476157032 doi "https://doi.org/10.1111/cea.12783" @default.
• W2476157032 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5042847" @default.
• W2476157032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27473664" @default.
• W2476157032 hasPublicationYear "2016" @default.
• W2476157032 type Work @default.
• W2476157032 sameAs 2476157032 @default.
• W2476157032 citedByCount "38" @default.
• W2476157032 countsByYear W24761570322017 @default.
• W2476157032 countsByYear W24761570322018 @default.
• W2476157032 countsByYear W24761570322019 @default.
• W2476157032 countsByYear W24761570322020 @default.
• W2476157032 countsByYear W24761570322021 @default.
• W2476157032 countsByYear W24761570322022 @default.
• W2476157032 countsByYear W24761570322023 @default.
• W2476157032 crossrefType "journal-article" @default.
• W2476157032 hasAuthorship W2476157032A5006246995 @default.

• next