FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2476167899> ?p ?o ?g. }

• W2476167899 endingPage "1019" @default.
• W2476167899 startingPage "1009" @default.
• W2476167899 abstract "The development of the transgenic mouse model carrying the infectious human hepatitis B virus (HBV) genome has been motivated in part by the expense and minimal availability of the HBV chimpanzee model, and the absence of more convenient, small non-primate animal models that can be infected with HBV. This chapter describes the features of the HBV-transgenic mice that produce appreciable levels of serum hepatitis B virions, as determined by the presence of HBV DNA and electron microscopy. The transgenic mice carry the infectious HBV genome integrated into the host genome. Consequently, the transgene is inherited to progeny animals by classical Mendelian genetics and the virus is not injected with exogenous inocula. Viral inoculum is not administered due to the presence of the HBV transgene. In transgenic mice, viral RNA and subsequent viral proteins and virions are generated from the HBV transgene integrated in the host genome. No death or even pathology has been identified in the transgenic mice that efficiently produce the complete viral particle. Consequently, viral parameters are used as indicators of drug efficacy for these mice. The viral particles and their serological determinants are similar between the transgenic mice and in human patients. As the infectious Dane-like particles are found in the transgenic mice, the antigens and viral DNAs associated with the Dane particles are found in the sera. The precore antigen, detected immunologically as the HBeAg, is rapidly secreted from the cells of the transgenic mice and is detected in the sera." @default.
• W2476167899 created "2016-08-23" @default.
• W2476167899 creator A5029074986 @default.
• W2476167899 creator A5030937108 @default.
• W2476167899 creator A5031975164 @default.
• W2476167899 date "1999-01-01" @default.
• W2476167899 modified "2023-10-14" @default.
• W2476167899 title "Animal Models for HBV Infections — Transgenic Mice" @default.
• W2476167899 cites W1487460156 @default.
• W2476167899 cites W1502826501 @default.
• W2476167899 cites W1515539841 @default.
• W2476167899 cites W1534821225 @default.
• W2476167899 cites W1540300718 @default.
• W2476167899 cites W1544473294 @default.
• W2476167899 cites W1547706575 @default.
• W2476167899 cites W1556400322 @default.
• W2476167899 cites W1565398120 @default.
• W2476167899 cites W1583015460 @default.
• W2476167899 cites W1767481873 @default.
• W2476167899 cites W1883539422 @default.
• W2476167899 cites W1885980745 @default.
• W2476167899 cites W1907523034 @default.
• W2476167899 cites W1915463129 @default.
• W2476167899 cites W1932939055 @default.
• W2476167899 cites W1933670444 @default.
• W2476167899 cites W1951553828 @default.
• W2476167899 cites W1977521763 @default.
• W2476167899 cites W1984848689 @default.
• W2476167899 cites W1984856806 @default.
• W2476167899 cites W1991355519 @default.
• W2476167899 cites W1997615170 @default.
• W2476167899 cites W2008054246 @default.
• W2476167899 cites W2026635284 @default.
• W2476167899 cites W2027704620 @default.
• W2476167899 cites W2042653073 @default.
• W2476167899 cites W2053069611 @default.
• W2476167899 cites W2054968862 @default.
• W2476167899 cites W2076684492 @default.
• W2476167899 cites W2088165891 @default.
• W2476167899 cites W2090973261 @default.
• W2476167899 cites W2092138793 @default.
• W2476167899 cites W2095427717 @default.
• W2476167899 cites W2101273158 @default.
• W2476167899 cites W2102960442 @default.
• W2476167899 cites W2129923672 @default.
• W2476167899 cites W2132190624 @default.
• W2476167899 cites W2170239355 @default.
• W2476167899 cites W2175117246 @default.
• W2476167899 cites W2313828088 @default.
• W2476167899 cites W2403058323 @default.
• W2476167899 cites W2411592464 @default.
• W2476167899 cites W2415086707 @default.
• W2476167899 cites W55293628 @default.
• W2476167899 doi "https://doi.org/10.1016/b978-012775390-4/50261-x" @default.
• W2476167899 hasPublicationYear "1999" @default.
• W2476167899 type Work @default.
• W2476167899 sameAs 2476167899 @default.
• W2476167899 citedByCount "2" @default.
• W2476167899 crossrefType "book-chapter" @default.
• W2476167899 hasAuthorship W2476167899A5029074986 @default.
• W2476167899 hasAuthorship W2476167899A5030937108 @default.
• W2476167899 hasAuthorship W2476167899A5031975164 @default.
• W2476167899 hasConcept C102230213 @default.
• W2476167899 hasConcept C104317684 @default.
• W2476167899 hasConcept C141035611 @default.
• W2476167899 hasConcept C141231307 @default.
• W2476167899 hasConcept C159047783 @default.
• W2476167899 hasConcept C2522874641 @default.
• W2476167899 hasConcept C2775940106 @default.
• W2476167899 hasConcept C2777410769 @default.
• W2476167899 hasConcept C2780593183 @default.
• W2476167899 hasConcept C2780617729 @default.
• W2476167899 hasConcept C54355233 @default.
• W2476167899 hasConcept C86803240 @default.
• W2476167899 hasConceptScore W2476167899C102230213 @default.
• W2476167899 hasConceptScore W2476167899C104317684 @default.
• W2476167899 hasConceptScore W2476167899C141035611 @default.
• W2476167899 hasConceptScore W2476167899C141231307 @default.
• W2476167899 hasConceptScore W2476167899C159047783 @default.
• W2476167899 hasConceptScore W2476167899C2522874641 @default.
• W2476167899 hasConceptScore W2476167899C2775940106 @default.
• W2476167899 hasConceptScore W2476167899C2777410769 @default.
• W2476167899 hasConceptScore W2476167899C2780593183 @default.
• W2476167899 hasConceptScore W2476167899C2780617729 @default.
• W2476167899 hasConceptScore W2476167899C54355233 @default.
• W2476167899 hasConceptScore W2476167899C86803240 @default.
• W2476167899 hasLocation W24761678991 @default.
• W2476167899 hasOpenAccess W2476167899 @default.
• W2476167899 hasPrimaryLocation W24761678991 @default.
• W2476167899 hasRelatedWork W1494523999 @default.
• W2476167899 hasRelatedWork W1965983990 @default.
• W2476167899 hasRelatedWork W2058381089 @default.
• W2476167899 hasRelatedWork W2095853007 @default.
• W2476167899 hasRelatedWork W2123555833 @default.
• W2476167899 hasRelatedWork W2145782156 @default.
• W2476167899 hasRelatedWork W2170511845 @default.
• W2476167899 hasRelatedWork W2291166135 @default.
• W2476167899 hasRelatedWork W2476167899 @default.

• next