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- W2476175588 abstract "Although carbonic anhydrase I (CA I) is one of the first CA isoforms discovered, its physiological and pathological functions are still poorly understood. Moreover, its role as a putative pharmacological target has not been validated yet. However, recent evidences highlighted that expression of CA I is involved in several diseases, and therefore the development of selective CA I modulators is expected. Structural and biological data are now available for this isozyme, and this information can be useful in the drug discovery process. To date, a plethora of potent CA inhibitors/activators have been identified, but only a few of them have demonstrated to be specific ligands of the CA I isoform. This chapter focuses on the structure and functions of CA I, with particular emphasis on its potential as a suitable drug target." @default.
- W2476175588 created "2016-08-23" @default.
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- W2476175588 date "2015-01-01" @default.
- W2476175588 modified "2023-09-26" @default.
- W2476175588 title "Carbonic Anhydrase I" @default.
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- W2476175588 doi "https://doi.org/10.1016/b978-0-444-63258-6.00003-2" @default.
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