Matches in SemOpenAlex for { <https://semopenalex.org/work/W2476244880> ?p ?o ?g. }
- W2476244880 abstract "Cytoplasmic dynein is the major minus-end-directed microtubule-based motor in nearly all eukaryotic cells. Due to its large size and subunit complexity, dissecting the motile properties of dynein has been challenging. However, recent advances in recombinant approaches to purify dynein, as well as studies with the native motors, have begun to reveal the details of how dynein steps along microtubules and responds to externally applied loads. Compared to studies on the other cytoskeletal motors, myosin and kinesin, studies of dynein are still in their infancy, leading to a number of controversies regarding the dynein motile mechanism. However, a consensus is beginning to emerge from single-molecule studies that dynein is a highly processive motor, which can take forward, backward and diagonal steps related in size to the minimum repeat unit of the microtubule (8 nm). Here we discuss some of the more controversial aspects of the dynein stepping mechanism and response to load. We also review what is known about dynein regulation by its multiple ATP-binding sites and associated cofactors, the dynactin complex, LIS1, and NudE." @default.
- W2476244880 created "2016-08-23" @default.
- W2476244880 creator A5021023250 @default.
- W2476244880 creator A5054594500 @default.
- W2476244880 creator A5091261902 @default.
- W2476244880 date "2012-01-01" @default.
- W2476244880 modified "2023-09-23" @default.
- W2476244880 title "Motile Properties of Cytoplasmic Dynein" @default.
- W2476244880 cites W102506034 @default.
- W2476244880 cites W1545569420 @default.
- W2476244880 cites W1581760465 @default.
- W2476244880 cites W1677326748 @default.
- W2476244880 cites W1963838580 @default.
- W2476244880 cites W1963851313 @default.
- W2476244880 cites W1964256847 @default.
- W2476244880 cites W1965151798 @default.
- W2476244880 cites W1965539063 @default.
- W2476244880 cites W1966790730 @default.
- W2476244880 cites W1968654429 @default.
- W2476244880 cites W1974276027 @default.
- W2476244880 cites W1975315168 @default.
- W2476244880 cites W1975975759 @default.
- W2476244880 cites W1978309689 @default.
- W2476244880 cites W1981662243 @default.
- W2476244880 cites W1982275607 @default.
- W2476244880 cites W1983083500 @default.
- W2476244880 cites W1989460321 @default.
- W2476244880 cites W1990341894 @default.
- W2476244880 cites W1990492988 @default.
- W2476244880 cites W1992502425 @default.
- W2476244880 cites W1993179342 @default.
- W2476244880 cites W2000479770 @default.
- W2476244880 cites W2001060611 @default.
- W2476244880 cites W2005633093 @default.
- W2476244880 cites W2008666091 @default.
- W2476244880 cites W2010958487 @default.
- W2476244880 cites W2015229379 @default.
- W2476244880 cites W2015404233 @default.
- W2476244880 cites W2017929785 @default.
- W2476244880 cites W2018694096 @default.
- W2476244880 cites W2018709028 @default.
- W2476244880 cites W2030311719 @default.
- W2476244880 cites W2031194197 @default.
- W2476244880 cites W2033001450 @default.
- W2476244880 cites W2033859483 @default.
- W2476244880 cites W2036000517 @default.
- W2476244880 cites W2036623899 @default.
- W2476244880 cites W2037835429 @default.
- W2476244880 cites W2039346234 @default.
- W2476244880 cites W2044668046 @default.
- W2476244880 cites W2051958637 @default.
- W2476244880 cites W2053376533 @default.
- W2476244880 cites W2060061334 @default.
- W2476244880 cites W2061432570 @default.
- W2476244880 cites W2064047527 @default.
- W2476244880 cites W2071577667 @default.
- W2476244880 cites W2072278366 @default.
- W2476244880 cites W2078056153 @default.
- W2476244880 cites W2079640553 @default.
- W2476244880 cites W2079981758 @default.
- W2476244880 cites W2083068431 @default.
- W2476244880 cites W2084729729 @default.
- W2476244880 cites W2085796374 @default.
- W2476244880 cites W2094760360 @default.
- W2476244880 cites W2095633207 @default.
- W2476244880 cites W2095790288 @default.
- W2476244880 cites W2096526911 @default.
- W2476244880 cites W2098889694 @default.
- W2476244880 cites W2105851524 @default.
- W2476244880 cites W2110488004 @default.
- W2476244880 cites W2110641277 @default.
- W2476244880 cites W2111299494 @default.
- W2476244880 cites W2115850825 @default.
- W2476244880 cites W2118642774 @default.
- W2476244880 cites W2119564290 @default.
- W2476244880 cites W2128427159 @default.
- W2476244880 cites W2128647989 @default.
- W2476244880 cites W2130272609 @default.
- W2476244880 cites W2131112743 @default.
- W2476244880 cites W2133664013 @default.
- W2476244880 cites W2138882854 @default.
- W2476244880 cites W2142726051 @default.
- W2476244880 cites W2144938845 @default.
- W2476244880 cites W2149151220 @default.
- W2476244880 cites W2157100231 @default.
- W2476244880 cites W2157133188 @default.
- W2476244880 cites W2157787219 @default.
- W2476244880 cites W2161796539 @default.
- W2476244880 cites W2162117855 @default.
- W2476244880 cites W2165839023 @default.
- W2476244880 cites W2167387669 @default.
- W2476244880 cites W2168002602 @default.
- W2476244880 cites W2170640142 @default.
- W2476244880 cites W2184740165 @default.
- W2476244880 cites W48740822 @default.
- W2476244880 hasPublicationYear "2012" @default.
- W2476244880 type Work @default.
- W2476244880 sameAs 2476244880 @default.
- W2476244880 citedByCount "0" @default.
- W2476244880 crossrefType "journal-article" @default.