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- W2476261036 abstract "Significance The outer membrane of Gram-negative bacteria provides a barrier that allows these organisms to live in a variety of harsh environments. Here, we study the machine responsible for the insertion of integral membrane β-barrel proteins into this outer membrane. How this barrel assembly machine (Bam) functions is unknown because it has not been possible to characterize substrates in the process of folding. We slowed the assembly of a substrate and observe a partially folded state still bound to the Bam complex. These studies define how and where folding occurs and the roles that the two essential components of the Bam complex play. Understanding how Bam works could enable development of compounds that inhibit its function and kill Gram-negative bacteria." @default.
- W2476261036 created "2016-08-23" @default.
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- W2476261036 date "2016-07-20" @default.
- W2476261036 modified "2023-10-11" @default.
- W2476261036 title "Characterization of a stalled complex on the β-barrel assembly machine" @default.
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- W2476261036 doi "https://doi.org/10.1073/pnas.1604100113" @default.
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