FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2476459745> ?p ?o ?g. }

• W2476459745 endingPage "2315" @default.
• W2476459745 startingPage "2301" @default.
• W2476459745 abstract "We have previously shown that physio/pathological levels of hydrogen peroxide (H2O2) stimulate translation from the hepatitis C virus (HCV) internal ribosome entry site (IRES) element in tissue-cultured cells. Here, using in vitro translation, we further show that H2O2 upregulates HCV IRES-dependent mRNA translation and correlates with an increase in intracellular oxidant level. Using Western blotting, immunocytochemistry, microscopy and affinity pulldown, we show that H2O2 stimulates HCV IRES-dependent translation and correlates with nuclear-cytoplasmic shuttling of the La autoantigen, resulting in enhanced binding of cytoplasmic La to HCV IRES RNA. The role of the La protein in H2O2-stimulated IRES-dependent translation is further confirmed by the ability of an anti-La antibody to suppress H2O2-activated IRES-dependent translation in vitro. This is further supported by the ability of an ectopically expressed dominant, negative La mutant protein to suppress H2O2-inducible IRES-mediated translation in Huh7 cells, transiently transfected with a bicistronic reporter and in a sub-genomic replicon cell line resembling a persistent infection. On the other hand, translation from the encephalomyocarditis virus IRES is diminished in the presence of H2O2, suggesting that H2O2 translational responsiveness is a specific property of the HCV IRES and is not a general phenomenon for all viral IRESs. Altogether, these results suggest that HCV adapts to physio/pathological oxidative stress in the host cell by mediating La cytoplasmic shuttling to enhance its IRES-dependent translation." @default.
• W2476459745 created "2016-08-23" @default.
• W2476459745 creator A5000666976 @default.
• W2476459745 date "2016-09-01" @default.
• W2476459745 modified "2023-09-26" @default.
• W2476459745 title "Hydrogen peroxide induces La cytoplasmic shuttling and increases hepatitis C virus internal ribosome entry site-dependent translation" @default.
• W2476459745 cites W1677068128 @default.
• W2476459745 cites W1869973645 @default.
• W2476459745 cites W1914838920 @default.
• W2476459745 cites W1965606292 @default.
• W2476459745 cites W1966914649 @default.
• W2476459745 cites W1969330771 @default.
• W2476459745 cites W1973673595 @default.
• W2476459745 cites W1975902897 @default.
• W2476459745 cites W1981278169 @default.
• W2476459745 cites W1989987141 @default.
• W2476459745 cites W1993943573 @default.
• W2476459745 cites W2004395625 @default.
• W2476459745 cites W2009651817 @default.
• W2476459745 cites W2010507403 @default.
• W2476459745 cites W2013506102 @default.
• W2476459745 cites W2015161791 @default.
• W2476459745 cites W2021527813 @default.
• W2476459745 cites W2024065761 @default.
• W2476459745 cites W2026466058 @default.
• W2476459745 cites W2029527720 @default.
• W2476459745 cites W2032611112 @default.
• W2476459745 cites W2034446867 @default.
• W2476459745 cites W2035922014 @default.
• W2476459745 cites W2045348184 @default.
• W2476459745 cites W2047807806 @default.
• W2476459745 cites W2049128728 @default.
• W2476459745 cites W2051250708 @default.
• W2476459745 cites W2054580868 @default.
• W2476459745 cites W2066694823 @default.
• W2476459745 cites W2068230037 @default.
• W2476459745 cites W2068782912 @default.
• W2476459745 cites W2078887917 @default.
• W2476459745 cites W2079310705 @default.
• W2476459745 cites W2080543752 @default.
• W2476459745 cites W2086842513 @default.
• W2476459745 cites W2087064069 @default.
• W2476459745 cites W2099940931 @default.
• W2476459745 cites W2102518477 @default.
• W2476459745 cites W2107492653 @default.
• W2476459745 cites W2113021398 @default.
• W2476459745 cites W2114267277 @default.
• W2476459745 cites W2114717600 @default.
• W2476459745 cites W2115768394 @default.
• W2476459745 cites W2119830122 @default.
• W2476459745 cites W2121440740 @default.
• W2476459745 cites W2124861729 @default.
• W2476459745 cites W2133866337 @default.
• W2476459745 cites W2144120294 @default.
• W2476459745 cites W2144195875 @default.
• W2476459745 cites W2145412955 @default.
• W2476459745 cites W2152243715 @default.
• W2476459745 cites W2155137251 @default.
• W2476459745 cites W2161954305 @default.
• W2476459745 cites W4238463235 @default.
• W2476459745 cites W4247599887 @default.
• W2476459745 doi "https://doi.org/10.1099/jgv.0.000556" @default.
• W2476459745 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5042130" @default.
• W2476459745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27436793" @default.
• W2476459745 hasPublicationYear "2016" @default.
• W2476459745 type Work @default.
• W2476459745 sameAs 2476459745 @default.
• W2476459745 citedByCount "8" @default.
• W2476459745 countsByYear W24764597452019 @default.
• W2476459745 countsByYear W24764597452020 @default.
• W2476459745 countsByYear W24764597452021 @default.
• W2476459745 countsByYear W24764597452022 @default.
• W2476459745 crossrefType "journal-article" @default.
• W2476459745 hasAuthorship W2476459745A5000666976 @default.
• W2476459745 hasBestOaLocation W24764597451 @default.
• W2476459745 hasConcept C104317684 @default.
• W2476459745 hasConcept C105580179 @default.
• W2476459745 hasConcept C149364088 @default.
• W2476459745 hasConcept C153911025 @default.
• W2476459745 hasConcept C159047783 @default.
• W2476459745 hasConcept C190062978 @default.
• W2476459745 hasConcept C3675279 @default.
• W2476459745 hasConcept C54009773 @default.
• W2476459745 hasConcept C54355233 @default.
• W2476459745 hasConcept C55493867 @default.
• W2476459745 hasConcept C67705224 @default.
• W2476459745 hasConcept C77430603 @default.
• W2476459745 hasConcept C81885089 @default.
• W2476459745 hasConcept C86803240 @default.
• W2476459745 hasConcept C88478588 @default.
• W2476459745 hasConcept C95444343 @default.
• W2476459745 hasConceptScore W2476459745C104317684 @default.
• W2476459745 hasConceptScore W2476459745C105580179 @default.
• W2476459745 hasConceptScore W2476459745C149364088 @default.
• W2476459745 hasConceptScore W2476459745C153911025 @default.
• W2476459745 hasConceptScore W2476459745C159047783 @default.
• W2476459745 hasConceptScore W2476459745C190062978 @default.
• W2476459745 hasConceptScore W2476459745C3675279 @default.

• next