Matches in SemOpenAlex for { <https://semopenalex.org/work/W2476500174> ?p ?o ?g. }
- W2476500174 abstract "Significance Upon infection, circulating leukocytes leave the bloodstream and migrate into the inflammatory site. Neutrophils are the first leukocytes to be recruited within a few hours, followed by inflammatory lymphocyte antigen 6 complex (Ly6C)-positive monocytes. This study refines the model of the leukocyte recruitment cascade. We demonstrate that upon Toll-like receptor 7/8-mediated vascular inflammation, platelet activation drives the rapid mobilization of Ly6C low monocytes to the luminal side of the endothelium. Accumulated Ly6C low monocytes do not extravasate into the tissue. Instead, they meticulously patrol the endothelium and control the subsequent recruitment of neutrophils. Moreover, we show that endothelium-bound cyteine-rich protein 61 (CYR61)/CYR61 connective tissue growth factor nephroblastoma overexpressed 1 (CCN1) protein provides a molecular support for adequate patrolling of Ly6C low monocytes in the steady state and under inflammatory conditions." @default.
- W2476500174 created "2016-08-23" @default.
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- W2476500174 date "2016-08-01" @default.
- W2476500174 modified "2023-10-13" @default.
- W2476500174 title "CCN1/CYR61-mediated meticulous patrolling by Ly6C <sup>low</sup> monocytes fuels vascular inflammation" @default.
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- W2476500174 doi "https://doi.org/10.1073/pnas.1607710113" @default.
- W2476500174 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4995973" @default.
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