FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2476530813> ?p ?o ?g. }

• W2476530813 abstract "Purpose: Gastric cancer (GC) is an aggressive cancer metastasizing with a high propensity for peritoneal dissemination and liver metastasis. Some studies have been shown that not only cancer cells but also their surrounding stroma, especially cancer-associated fibroblasts (CAFs) play an important role in tumor development. Previously, we reported that CXCL12-CXCR4 and integrin β1 signal activation by CAFs co-operates for promoting FAK phosphorylation and enhances the invasiveness of GC cells in extracellular matrix (ECM).On the other hand, a previous study presented that CXCR4 and integrin signaling co-operates in mediating adhesion and chemoresistance in small cell lung cancer cells. Therefore, we hypothesized that CXCL12-CXCR4 and integrin signal activation by CAFs enhances the chemoresistance in GC as well. The aim of current study is to elucidate the significance of CAFs mediating signal activation for chemoresistance in GCs. Experimental Design: We first performed chemo-sensitive assays using GC cells cultured with fresh medium or with CAF-conditioned-medium (CM), and these experiments were conducted on non-coated and Matrigel-coated plates. Next, we examined the CXCL12-CXCR4 and integrin related signaling by western blotting analysis. Furthermore, we investigated the critical molecule for chemoresistance using silencing CXCR4 or integrin β1 in GC cells. Results: Chemo-sensitive assays revealed that GC cells cultured with CAF-CM showed more resistant to cisplatin and reactive oxygen spices (ROS) than those cultured with fresh medium. Moreover, GC cells with CAF-CM on Matrigel-coated plates exhibited remarkable resistance in these assays. On the other hand, western blotting analysis showed that Akt activity in GC cells cultured with CAF-CM was up-regulated in concurrence with FAK phosphorylation. Finally, the chemoresitance induced by CAFs was significantly suppressed by CXCR4 or integrin β1 silencing. Conclusions: These results suggest that CXCL12/CXCR4 and integrinβ1 signal activation by CAFs promoted the chemoresistance through enhancing their interaction with ECM in GC. This mechanism underlying the chemoresistance may provide a novel therapeutic target in advanced GCs. Citation Format: Yuka Tamaoki, Takatsugu Ishimoto, Keisuke Miyake, Daisuke Izumi, Daisuke Kuroda, Tsugio Eto, Kota Arima, Hironobu Shigaki, Junji Kurashige, Masaaki Iwatsuki, Yoshifumi Baba, Yasuo Sakamoto, Naoya Yoshida, Hideo Baba. CXCL12/CXCR4 and integrin signal activation by cancer-associated fibroblasts enhances the chemoresistance in gastric cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 5113." @default.
• W2476530813 created "2016-08-23" @default.
• W2476530813 creator A5017449862 @default.
• W2476530813 creator A5018669075 @default.
• W2476530813 creator A5030161279 @default.
• W2476530813 creator A5042469555 @default.
• W2476530813 creator A5052291346 @default.
• W2476530813 creator A5060949471 @default.
• W2476530813 creator A5065226133 @default.
• W2476530813 creator A5068472732 @default.
• W2476530813 creator A5069125187 @default.
• W2476530813 creator A5069774184 @default.
• W2476530813 creator A5072201531 @default.
• W2476530813 creator A5079811694 @default.
• W2476530813 creator A5084734266 @default.
• W2476530813 creator A5091140143 @default.
• W2476530813 date "2016-07-15" @default.
• W2476530813 modified "2023-09-25" @default.
• W2476530813 title "Abstract 5113: CXCL12/CXCR4 and integrin signal activation by cancer-associated fibroblasts enhances the chemoresistance in gastric cancer" @default.
• W2476530813 doi "https://doi.org/10.1158/1538-7445.am2016-5113" @default.
• W2476530813 hasPublicationYear "2016" @default.
• W2476530813 type Work @default.
• W2476530813 sameAs 2476530813 @default.
• W2476530813 citedByCount "0" @default.
• W2476530813 crossrefType "proceedings-article" @default.
• W2476530813 hasAuthorship W2476530813A5017449862 @default.
• W2476530813 hasAuthorship W2476530813A5018669075 @default.
• W2476530813 hasAuthorship W2476530813A5030161279 @default.
• W2476530813 hasAuthorship W2476530813A5042469555 @default.
• W2476530813 hasAuthorship W2476530813A5052291346 @default.
• W2476530813 hasAuthorship W2476530813A5060949471 @default.
• W2476530813 hasAuthorship W2476530813A5065226133 @default.
• W2476530813 hasAuthorship W2476530813A5068472732 @default.
• W2476530813 hasAuthorship W2476530813A5069125187 @default.
• W2476530813 hasAuthorship W2476530813A5069774184 @default.
• W2476530813 hasAuthorship W2476530813A5072201531 @default.
• W2476530813 hasAuthorship W2476530813A5079811694 @default.
• W2476530813 hasAuthorship W2476530813A5084734266 @default.
• W2476530813 hasAuthorship W2476530813A5091140143 @default.
• W2476530813 hasConcept C104317684 @default.
• W2476530813 hasConcept C121608353 @default.
• W2476530813 hasConcept C126322002 @default.
• W2476530813 hasConcept C1491633281 @default.
• W2476530813 hasConcept C185592680 @default.
• W2476530813 hasConcept C195687474 @default.
• W2476530813 hasConcept C2778608917 @default.
• W2476530813 hasConcept C2779013556 @default.
• W2476530813 hasConcept C2780394083 @default.
• W2476530813 hasConcept C2909706936 @default.
• W2476530813 hasConcept C502942594 @default.
• W2476530813 hasConcept C55493867 @default.
• W2476530813 hasConcept C71924100 @default.
• W2476530813 hasConcept C85265743 @default.
• W2476530813 hasConcept C86803240 @default.
• W2476530813 hasConcept C95444343 @default.
• W2476530813 hasConcept C96232424 @default.
• W2476530813 hasConceptScore W2476530813C104317684 @default.
• W2476530813 hasConceptScore W2476530813C121608353 @default.
• W2476530813 hasConceptScore W2476530813C126322002 @default.
• W2476530813 hasConceptScore W2476530813C1491633281 @default.
• W2476530813 hasConceptScore W2476530813C185592680 @default.
• W2476530813 hasConceptScore W2476530813C195687474 @default.
• W2476530813 hasConceptScore W2476530813C2778608917 @default.
• W2476530813 hasConceptScore W2476530813C2779013556 @default.
• W2476530813 hasConceptScore W2476530813C2780394083 @default.
• W2476530813 hasConceptScore W2476530813C2909706936 @default.
• W2476530813 hasConceptScore W2476530813C502942594 @default.
• W2476530813 hasConceptScore W2476530813C55493867 @default.
• W2476530813 hasConceptScore W2476530813C71924100 @default.
• W2476530813 hasConceptScore W2476530813C85265743 @default.
• W2476530813 hasConceptScore W2476530813C86803240 @default.
• W2476530813 hasConceptScore W2476530813C95444343 @default.
• W2476530813 hasConceptScore W2476530813C96232424 @default.
• W2476530813 hasLocation W24765308131 @default.
• W2476530813 hasOpenAccess W2476530813 @default.
• W2476530813 hasPrimaryLocation W24765308131 @default.
• W2476530813 hasRelatedWork W1978658896 @default.
• W2476530813 hasRelatedWork W1995090479 @default.
• W2476530813 hasRelatedWork W2102829128 @default.
• W2476530813 hasRelatedWork W2207122568 @default.
• W2476530813 hasRelatedWork W2502599913 @default.
• W2476530813 hasRelatedWork W2561162897 @default.
• W2476530813 hasRelatedWork W2810023065 @default.
• W2476530813 hasRelatedWork W2861250537 @default.
• W2476530813 hasRelatedWork W2898316705 @default.
• W2476530813 hasRelatedWork W2903970826 @default.
• W2476530813 hasRelatedWork W2912578916 @default.
• W2476530813 hasRelatedWork W2921558231 @default.
• W2476530813 hasRelatedWork W2944887118 @default.
• W2476530813 hasRelatedWork W2998632221 @default.
• W2476530813 hasRelatedWork W3038930186 @default.
• W2476530813 hasRelatedWork W3042518384 @default.
• W2476530813 hasRelatedWork W3084590176 @default.
• W2476530813 hasRelatedWork W3158934247 @default.
• W2476530813 hasRelatedWork W3192649574 @default.
• W2476530813 hasRelatedWork W2231809043 @default.
• W2476530813 isParatext "false" @default.
• W2476530813 isRetracted "false" @default.
• W2476530813 magId "2476530813" @default.
• W2476530813 workType "article" @default.