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- W2476546154 startingPage "59" @default.
- W2476546154 abstract "The main and only modifiable risk factor in glaucoma, the group of usually late onset progressive and irreversible blinding optic neuropathies, is elevated intraocular pressure (IOP). The increase in IOP is due to impeded aqueous humor (AH) outflow through the conventional pathway. The aberrant increased resistance at the trabecular meshwork (TM), the filter-like region in the anterior eye chamber is the major contributory factor in causing the impeded outflow. In normal as well as in glaucoma eyes the regions of the TM are divided into areas of high and low flow. The collector channels and distal outflow regions are now increasingly being recognized as potential players in contributing to impede AH outflow. Structural and molecular make-up contributing to the segmental blockage to outflow is likely to provide greater insight. Establishing segmental blockage to outflow in model systems of glaucoma such as the mouse in parallel to human eyes will expand our repertoire of tools for investigation. Further study into this area of interest has the potential to ultimately lead to the development of new therapeutics focused on lowering IOP by targeting the various components of segmental blockage of outflow in the TM and in the distal outflow region." @default.
- W2476546154 created "2016-08-23" @default.
- W2476546154 creator A5022728200 @default.
- W2476546154 creator A5027407201 @default.
- W2476546154 creator A5063733811 @default.
- W2476546154 creator A5067107146 @default.
- W2476546154 date "2017-05-01" @default.
- W2476546154 modified "2023-09-30" @default.
- W2476546154 title "Segmental outflow of aqueous humor in mouse and human" @default.
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