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- W2476560450 abstract "Viral replication by acquisition of the host cell biology represents a central part of a virus life cycle. Thereby, integration into the host genome constitutes a successful strategy to ensure viral persistence and viruses have developed different mechanisms to integrate and benefit from cell's transcriptional and translational machinery. While lentiviral (e.g. HIV) integration is influenced by the chromatin landscape encountered upon nuclear entry, certain parvoviruses (e.g. AAV) integrate specifically within genomic regions bearing increasingly known sequence motifs. Gene therapy exploits these viral persistence strategies to achieve efficient and safe long-term transgene expression. Here we focus on two widely used vectors and their parental viruses, HIV and AAV, to discuss recent insights into lentiviral vector oncogenicity by alteration of endogenous transcripts as well as the unresolved AAV vectors genotoxic potential." @default.
- W2476560450 created "2016-08-23" @default.
- W2476560450 creator A5044943938 @default.
- W2476560450 creator A5060449046 @default.
- W2476560450 date "2016-12-01" @default.
- W2476560450 modified "2023-09-26" @default.
- W2476560450 title "Interaction of vectors and parental viruses with the host genome" @default.
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- W2476560450 doi "https://doi.org/10.1016/j.coviro.2016.07.004" @default.
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