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- W2476574516 startingPage "169" @default.
- W2476574516 abstract "Targeting epigenetic aberrations in cancer is now referred as to epigenetic therapy and targeting DNA hypermethylation specifically has been very successful in the treatment of leukemias. Two cytosine analogs inducing DNA methyltransferase inhibition, 5-azacytidine and 5-aza-2′-deoxycytidine, have been approved for the treatment of myelodysplastic syndromes (MDS) and acute myelogenous leukemia. Hypomethylating drugs induce reactivation of silenced tumor suppressor genes and cancer cell differentiation at low doses. In patients with MDS, these epigenetic drugs reduce transfusion frequency and prolong survival. Preclinical research and clinical trials are being pursued to improve their clinical efficacy and to understand the mechanisms of drug resistance. A second generation of DNA methyltransferase inhibitors were designed to address these issues and are currently in clinical trials. In this chapter, we will focus on the mechanism of action of 5-azacytidine and 5-aza-2′-deoxycytidine and highlight the historical and future perspective of DNA methyltransferase inhibitors." @default.
- W2476574516 created "2016-08-23" @default.
- W2476574516 creator A5038157289 @default.
- W2476574516 creator A5062330946 @default.
- W2476574516 date "2016-01-01" @default.
- W2476574516 modified "2023-10-18" @default.
- W2476574516 title "DNA Methyltransferase Inhibitors" @default.
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