Matches in SemOpenAlex for { <https://semopenalex.org/work/W2476663368> ?p ?o ?g. }
- W2476663368 abstract "The rapid spread of antibiotic resistance - currently one of the greatest threats to human health according to WHO - is to a large extent enabled by plasmid-mediated horizontal transfer of resistance genes. Rapid identification and characterization of plasmids is thus important both for individual clinical outcomes and for epidemiological monitoring of antibiotic resistance. Toward this aim, we have developed an optical DNA mapping procedure where individual intact plasmids are elongated within nanofluidic channels and visualized through fluorescence microscopy, yielding barcodes that reflect the underlying sequence. The assay rapidly identifies plasmids through statistical comparisons with barcodes based on publicly available sequence repositories and also enables detection of structural variations. Since the assay yields holistic sequence information for individual intact plasmids, it is an ideal complement to next generation sequencing efforts which involve reassembly of sequence reads from fragmented DNA molecules. The assay should be applicable in microbiology labs around the world in applications ranging from fundamental plasmid biology to clinical epidemiology and diagnostics." @default.
- W2476663368 created "2016-08-23" @default.
- W2476663368 creator A5014134922 @default.
- W2476663368 creator A5015827091 @default.
- W2476663368 creator A5020701444 @default.
- W2476663368 creator A5024856512 @default.
- W2476663368 creator A5026908087 @default.
- W2476663368 creator A5038851363 @default.
- W2476663368 creator A5053613669 @default.
- W2476663368 creator A5057911583 @default.
- W2476663368 creator A5058602768 @default.
- W2476663368 creator A5059488987 @default.
- W2476663368 creator A5060113553 @default.
- W2476663368 creator A5062250473 @default.
- W2476663368 creator A5069848534 @default.
- W2476663368 creator A5084196794 @default.
- W2476663368 creator A5090791975 @default.
- W2476663368 date "2016-07-27" @default.
- W2476663368 modified "2023-10-16" @default.
- W2476663368 title "Rapid identification of intact bacterial resistance plasmids via optical mapping of single DNA molecules" @default.
- W2476663368 cites W1553714112 @default.
- W2476663368 cites W1791377616 @default.
- W2476663368 cites W1810935850 @default.
- W2476663368 cites W1902535075 @default.
- W2476663368 cites W1965869751 @default.
- W2476663368 cites W1985739779 @default.
- W2476663368 cites W1994980002 @default.
- W2476663368 cites W1996655685 @default.
- W2476663368 cites W1996982236 @default.
- W2476663368 cites W2006699806 @default.
- W2476663368 cites W2012012446 @default.
- W2476663368 cites W2013063066 @default.
- W2476663368 cites W2033713614 @default.
- W2476663368 cites W2042031984 @default.
- W2476663368 cites W2055491807 @default.
- W2476663368 cites W2058415702 @default.
- W2476663368 cites W2061680337 @default.
- W2476663368 cites W2065337857 @default.
- W2476663368 cites W2065380874 @default.
- W2476663368 cites W2075344389 @default.
- W2476663368 cites W2079513697 @default.
- W2476663368 cites W2094519647 @default.
- W2476663368 cites W2110317284 @default.
- W2476663368 cites W2114610435 @default.
- W2476663368 cites W2119359503 @default.
- W2476663368 cites W2122386510 @default.
- W2476663368 cites W2126853503 @default.
- W2476663368 cites W2131865558 @default.
- W2476663368 cites W2146527067 @default.
- W2476663368 cites W2153049318 @default.
- W2476663368 cites W2154126034 @default.
- W2476663368 cites W2162093394 @default.
- W2476663368 cites W2169550448 @default.
- W2476663368 cites W2179036997 @default.
- W2476663368 cites W2203319208 @default.
- W2476663368 cites W2318152076 @default.
- W2476663368 doi "https://doi.org/10.1038/srep30410" @default.
- W2476663368 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4961956" @default.
- W2476663368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27460437" @default.
- W2476663368 hasPublicationYear "2016" @default.
- W2476663368 type Work @default.
- W2476663368 sameAs 2476663368 @default.
- W2476663368 citedByCount "39" @default.
- W2476663368 countsByYear W24766633682016 @default.
- W2476663368 countsByYear W24766633682017 @default.
- W2476663368 countsByYear W24766633682018 @default.
- W2476663368 countsByYear W24766633682019 @default.
- W2476663368 countsByYear W24766633682020 @default.
- W2476663368 countsByYear W24766633682021 @default.
- W2476663368 countsByYear W24766633682022 @default.
- W2476663368 countsByYear W24766633682023 @default.
- W2476663368 crossrefType "journal-article" @default.
- W2476663368 hasAuthorship W2476663368A5014134922 @default.
- W2476663368 hasAuthorship W2476663368A5015827091 @default.
- W2476663368 hasAuthorship W2476663368A5020701444 @default.
- W2476663368 hasAuthorship W2476663368A5024856512 @default.
- W2476663368 hasAuthorship W2476663368A5026908087 @default.
- W2476663368 hasAuthorship W2476663368A5038851363 @default.
- W2476663368 hasAuthorship W2476663368A5053613669 @default.
- W2476663368 hasAuthorship W2476663368A5057911583 @default.
- W2476663368 hasAuthorship W2476663368A5058602768 @default.
- W2476663368 hasAuthorship W2476663368A5059488987 @default.
- W2476663368 hasAuthorship W2476663368A5060113553 @default.
- W2476663368 hasAuthorship W2476663368A5062250473 @default.
- W2476663368 hasAuthorship W2476663368A5069848534 @default.
- W2476663368 hasAuthorship W2476663368A5084196794 @default.
- W2476663368 hasAuthorship W2476663368A5090791975 @default.
- W2476663368 hasBestOaLocation W24766633681 @default.
- W2476663368 hasConcept C104317684 @default.
- W2476663368 hasConcept C116834253 @default.
- W2476663368 hasConcept C141231307 @default.
- W2476663368 hasConcept C180223184 @default.
- W2476663368 hasConcept C22744801 @default.
- W2476663368 hasConcept C2778112365 @default.
- W2476663368 hasConcept C51679486 @default.
- W2476663368 hasConcept C523546767 @default.
- W2476663368 hasConcept C54355233 @default.
- W2476663368 hasConcept C547475151 @default.
- W2476663368 hasConcept C552990157 @default.
- W2476663368 hasConcept C59822182 @default.