Matches in SemOpenAlex for { <https://semopenalex.org/work/W2476668155> ?p ?o ?g. }
- W2476668155 abstract "Abstract This chapter summarizes the associations between brain systems measured with imaging and biological markers of stress in major depressive disorder (MDD). Within the stress system, hippocampal volumes and altered brain function are associated with hypothalamic–pituitary–adrenal (HPA) axis dysregulation. There is also evidence that inflammatory markers that are associated with the stress system and HPA axis dysfunction are also associated with changes in brain structure and function. Changes in the neurotrophic and the neurotransmitter systems such as the serotonergic system have an impact on brain development, and associations between these systems and functional and structural brain changes in depression have been described. It seems very likely that a model integrating childhood maltreatment, HPA axis abnormalities, decreases in neurotrophic factors, and alterations in neurotransmission and inflammatory states, and moderated by genetics needs to be established to provide a cohesive explanation of all the findings. When one of these integrated systems gets altered, the whole functional balance is disturbed, probably resulting in psychiatric syndromes like depression. The hope would be that through disentangling these system changes, different subtypes of depression will be defined based on neurobiological pathways. Thus, a diagnosis might be based on pathophysiological changes rather than behavioral assessments." @default.
- W2476668155 created "2016-08-23" @default.
- W2476668155 creator A5020131072 @default.
- W2476668155 creator A5030301014 @default.
- W2476668155 date "2016-01-01" @default.
- W2476668155 modified "2023-09-26" @default.
- W2476668155 title "Integrating the Stress Systems and Neuroimaging in Depression" @default.
- W2476668155 cites W1142017 @default.
- W2476668155 cites W1485848540 @default.
- W2476668155 cites W1504438818 @default.
- W2476668155 cites W1520184724 @default.
- W2476668155 cites W1793086031 @default.
- W2476668155 cites W1915403575 @default.
- W2476668155 cites W1939264572 @default.
- W2476668155 cites W1963629744 @default.
- W2476668155 cites W1964884387 @default.
- W2476668155 cites W1967184958 @default.
- W2476668155 cites W1968019821 @default.
- W2476668155 cites W1969495575 @default.
- W2476668155 cites W1971295949 @default.
- W2476668155 cites W1974102924 @default.
- W2476668155 cites W1976711431 @default.
- W2476668155 cites W1977143695 @default.
- W2476668155 cites W1978474530 @default.
- W2476668155 cites W1979326572 @default.
- W2476668155 cites W1979956591 @default.
- W2476668155 cites W1980912056 @default.
- W2476668155 cites W1980921374 @default.
- W2476668155 cites W1987604172 @default.
- W2476668155 cites W1989615119 @default.
- W2476668155 cites W1990189386 @default.
- W2476668155 cites W1991116655 @default.
- W2476668155 cites W1991692932 @default.
- W2476668155 cites W1992326063 @default.
- W2476668155 cites W1992525659 @default.
- W2476668155 cites W1993355744 @default.
- W2476668155 cites W1993944527 @default.
- W2476668155 cites W1994212722 @default.
- W2476668155 cites W1996454121 @default.
- W2476668155 cites W1996941358 @default.
- W2476668155 cites W1997491128 @default.
- W2476668155 cites W2002101479 @default.
- W2476668155 cites W2005103919 @default.
- W2476668155 cites W2007636259 @default.
- W2476668155 cites W2008113854 @default.
- W2476668155 cites W2011812102 @default.
- W2476668155 cites W2013373204 @default.
- W2476668155 cites W2014535273 @default.
- W2476668155 cites W2016276336 @default.
- W2476668155 cites W2017181469 @default.
- W2476668155 cites W2017570880 @default.
- W2476668155 cites W2019092555 @default.
- W2476668155 cites W2020113570 @default.
- W2476668155 cites W2020216083 @default.
- W2476668155 cites W2021030890 @default.
- W2476668155 cites W2023068980 @default.
- W2476668155 cites W2023238505 @default.
- W2476668155 cites W2024917272 @default.
- W2476668155 cites W2025187757 @default.
- W2476668155 cites W2026328830 @default.
- W2476668155 cites W2026820213 @default.
- W2476668155 cites W2030928752 @default.
- W2476668155 cites W2031360902 @default.
- W2476668155 cites W2032136671 @default.
- W2476668155 cites W2033482605 @default.
- W2476668155 cites W2034630933 @default.
- W2476668155 cites W2034761715 @default.
- W2476668155 cites W2036814814 @default.
- W2476668155 cites W2037027327 @default.
- W2476668155 cites W2037617762 @default.
- W2476668155 cites W2038492389 @default.
- W2476668155 cites W2038771513 @default.
- W2476668155 cites W2040421938 @default.
- W2476668155 cites W2040546819 @default.
- W2476668155 cites W2040671975 @default.
- W2476668155 cites W2040912840 @default.
- W2476668155 cites W2042170262 @default.
- W2476668155 cites W2042473905 @default.
- W2476668155 cites W2042787057 @default.
- W2476668155 cites W2043314192 @default.
- W2476668155 cites W2043480169 @default.
- W2476668155 cites W2044092930 @default.
- W2476668155 cites W2045217506 @default.
- W2476668155 cites W2045758998 @default.
- W2476668155 cites W2045881156 @default.
- W2476668155 cites W2046297778 @default.
- W2476668155 cites W2046572145 @default.
- W2476668155 cites W2047159816 @default.
- W2476668155 cites W2048578851 @default.
- W2476668155 cites W2051550544 @default.
- W2476668155 cites W2053020615 @default.
- W2476668155 cites W2055747883 @default.
- W2476668155 cites W2057569019 @default.
- W2476668155 cites W2057988711 @default.
- W2476668155 cites W2058297450 @default.
- W2476668155 cites W2061196406 @default.
- W2476668155 cites W2061561049 @default.
- W2476668155 cites W2062682953 @default.
- W2476668155 cites W206355613 @default.
- W2476668155 cites W2064212981 @default.