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- W2476799087 endingPage "730" @default.
- W2476799087 startingPage "721" @default.
- W2476799087 abstract "Based on its wide expression in immune cells, type-2 cannabinoid (CB2) receptors were traditionally thought to act as ⿿peripheral receptors⿿ with an almost exclusively immunomodulatory function. However, their recent identification in mammalian brain areas, as well as in distinct neuronal cells, has opened the way to a re-consideration of CB2 signaling in the context of brain pathophysiology, synaptic plasticity and neuroprotection. To date, accumulated evidence from several independent preclinical studies has offered new perspectives on the possible involvement of CB2 signaling in brain and spinal cord traumatic injury, as well as in the most relevant neurodegenerative disorders like Alzheimer⿿s disease, Parkinson⿿s disease and Huntington⿿s chorea. Here, we will review available information on CB2 in these disease conditions, along with data that support also its therapeutic potential to treat them." @default.
- W2476799087 created "2016-08-23" @default.
- W2476799087 creator A5003387444 @default.
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- W2476799087 creator A5073191112 @default.
- W2476799087 creator A5084489352 @default.
- W2476799087 creator A5089479868 @default.
- W2476799087 date "2016-09-01" @default.
- W2476799087 modified "2023-10-10" @default.
- W2476799087 title "Type-2 cannabinoid receptors in neurodegeneration" @default.
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