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- W2476847493 abstract "Mucosal defenses are primarily directed to prevention and elimination of infection. The gastrointestinal tract has proved a very productive site for the study of mucosal immune responses, but in global terms far more lethal infections enter via the respiratory than the gastrointestinal route. Infections of the respiratory and intestinal tract constitute major threats to worldwide health. Together, these mucosal infections are the leading causes of morbidity and mortality in children. Respiratory syncytial virus (RSV) is a major worldwide childhood respiratory pathogen and an unsolved challenge for vaccine development. Clinically, infection is characterized by symptoms and signs of bronchial narrowing, and many children who recover from bronchiolitis are subsequently diagnosed as asthmatic. The mouse model of RSV lung disease has been very successful in reproducing many aspects of the human disease. In this species, some types of vaccination induce virus-specific T helper 2 cells. During subsequent RSV infection, lung eosinophilia develops. These and other studies have shown the dual role of anti-viral T cells in both eliminating virus and causing enhanced disease. This immunopathological paradox is now more clearly understood for RSV disease than for that caused by any other common human infection. This chapter presents a selection of current knowledge about the characteristics, functions, benefit, and harm of antiviral immune responses to RSV." @default.
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- W2476847493 date "1996-01-01" @default.
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- W2476847493 title "Beneficial and Harmful Immune Responses in the Respiratory Tract" @default.
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- W2476847493 doi "https://doi.org/10.1016/b978-012394330-9/50034-x" @default.
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