FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2476868632> ?p ?o ?g. }

• W2476868632 endingPage "8574" @default.
• W2476868632 startingPage "8563" @default.
• W2476868632 abstract "In chronic hepatitis B (CHB), failure to control hepatitis B virus (HBV) is associated with T cell dysfunction. HBV transgenic mice mirror many features of the human disease, including T cell unresponsiveness, and thus represent an appropriate model in which to test novel therapeutic strategies. To date, the tolerant state of CD8(+) T cells in these animals could be altered only by strong immunogens or by immunization with HBV antigen-pulsed dendritic cells; however, the effectors induced were unable to suppress viral gene expression or replication. Because of the known stimulatory properties of alpha interferon (IFN-α) and interleukin-15 (IL-15), this study explored the therapeutic potential of liver-directed gene transfer of these cytokines in a murine model of CHB using adeno-associated virus (AAV) delivery. This combination not only resulted in a reduction in the viral load in the liver and the induction of an antibody response but also gave rise to functional and specific CD8(+) immunity. Furthermore, when splenic and intrahepatic lymphocytes from IFN-α- and IL-15-treated animals were transferred to new HBV carriers, partial antiviral immunity was achieved. In contrast to previous observations made using either cytokine alone, markedly attenuated PD-L1 induction in hepatic tissue was observed upon coadministration. An initial study with CHB patient samples also gave promising results. Hence, we demonstrated synergy between two stimulating cytokines, IL-15 and IFN-α, which, given together, constitute a potent approach to significantly enhance the CD8(+) T cell response in a state of immune hyporesponsiveness. Such an approach may be useful for treating chronic viral infections and neoplastic conditions.With 350 million people affected worldwide and 600,000 annual deaths due to HBV-induced liver cirrhosis and/or hepatocellular carcinoma, chronic hepatitis B (CHB) is a major health problem. However, current treatment options are costly and not very effective and/or need to be administered for life. The unprecedented efficacy of the strategy described in our paper may offer an alternative and is relevant for a broad spectrum of readers because of its clear translational importance to other chronic viral infections in which a hyporesponsive antigen-specific T cell repertoire prevents clearance of the pathogen." @default.
• W2476868632 created "2016-08-23" @default.
• W2476868632 creator A5002412589 @default.
• W2476868632 creator A5011904150 @default.
• W2476868632 creator A5020031096 @default.
• W2476868632 creator A5028657023 @default.
• W2476868632 creator A5036980241 @default.
• W2476868632 creator A5039150247 @default.
• W2476868632 creator A5044943938 @default.
• W2476868632 creator A5048313418 @default.
• W2476868632 creator A5054743810 @default.
• W2476868632 creator A5056375160 @default.
• W2476868632 creator A5069905573 @default.
• W2476868632 creator A5074495073 @default.
• W2476868632 creator A5080356539 @default.
• W2476868632 creator A5085632483 @default.
• W2476868632 date "2016-10-01" @default.
• W2476868632 modified "2023-10-18" @default.
• W2476868632 title "Complementary Effects of Interleukin-15 and Alpha Interferon Induce Immunity in Hepatitis B Virus Transgenic Mice" @default.
• W2476868632 cites W1505315838 @default.
• W2476868632 cites W1893566975 @default.
• W2476868632 cites W1910012553 @default.
• W2476868632 cites W1925864442 @default.
• W2476868632 cites W1949743561 @default.
• W2476868632 cites W1967829528 @default.
• W2476868632 cites W1968138311 @default.
• W2476868632 cites W1969776963 @default.
• W2476868632 cites W1972194314 @default.
• W2476868632 cites W1988711873 @default.
• W2476868632 cites W1997443441 @default.
• W2476868632 cites W2000729283 @default.
• W2476868632 cites W2003831905 @default.
• W2476868632 cites W2003853324 @default.
• W2476868632 cites W2018182819 @default.
• W2476868632 cites W2023658793 @default.
• W2476868632 cites W2024556668 @default.
• W2476868632 cites W2030313067 @default.
• W2476868632 cites W2049868800 @default.
• W2476868632 cites W2051173965 @default.
• W2476868632 cites W2064823659 @default.
• W2476868632 cites W2068079563 @default.
• W2476868632 cites W2070770310 @default.
• W2476868632 cites W2071267501 @default.
• W2476868632 cites W2072963589 @default.
• W2476868632 cites W2097779928 @default.
• W2476868632 cites W2101273158 @default.
• W2476868632 cites W2118780236 @default.
• W2476868632 cites W2124748983 @default.
• W2476868632 cites W2128150974 @default.
• W2476868632 cites W2130850500 @default.
• W2476868632 cites W2131129763 @default.
• W2476868632 cites W2131605289 @default.
• W2476868632 cites W2132205831 @default.
• W2476868632 cites W2138927183 @default.
• W2476868632 cites W2139175652 @default.
• W2476868632 cites W2147176005 @default.
• W2476868632 cites W2148615881 @default.
• W2476868632 cites W2152095262 @default.
• W2476868632 cites W2155464214 @default.
• W2476868632 cites W2158393416 @default.
• W2476868632 cites W2168490317 @default.
• W2476868632 cites W2170114587 @default.
• W2476868632 cites W2234448540 @default.
• W2476868632 cites W2333436982 @default.
• W2476868632 cites W2439756494 @default.
• W2476868632 doi "https://doi.org/10.1128/jvi.01030-16" @default.
• W2476868632 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5021417" @default.
• W2476868632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27440883" @default.
• W2476868632 hasPublicationYear "2016" @default.
• W2476868632 type Work @default.
• W2476868632 sameAs 2476868632 @default.
• W2476868632 citedByCount "15" @default.
• W2476868632 countsByYear W24768686322017 @default.
• W2476868632 countsByYear W24768686322018 @default.
• W2476868632 countsByYear W24768686322019 @default.
• W2476868632 countsByYear W24768686322020 @default.
• W2476868632 countsByYear W24768686322021 @default.
• W2476868632 countsByYear W24768686322022 @default.
• W2476868632 crossrefType "journal-article" @default.
• W2476868632 hasAuthorship W2476868632A5002412589 @default.
• W2476868632 hasAuthorship W2476868632A5011904150 @default.
• W2476868632 hasAuthorship W2476868632A5020031096 @default.
• W2476868632 hasAuthorship W2476868632A5028657023 @default.
• W2476868632 hasAuthorship W2476868632A5036980241 @default.
• W2476868632 hasAuthorship W2476868632A5039150247 @default.
• W2476868632 hasAuthorship W2476868632A5044943938 @default.
• W2476868632 hasAuthorship W2476868632A5048313418 @default.
• W2476868632 hasAuthorship W2476868632A5054743810 @default.
• W2476868632 hasAuthorship W2476868632A5056375160 @default.
• W2476868632 hasAuthorship W2476868632A5069905573 @default.
• W2476868632 hasAuthorship W2476868632A5074495073 @default.
• W2476868632 hasAuthorship W2476868632A5080356539 @default.
• W2476868632 hasAuthorship W2476868632A5085632483 @default.
• W2476868632 hasBestOaLocation W24768686321 @default.
• W2476868632 hasConcept C159047783 @default.
• W2476868632 hasConcept C167672396 @default.
• W2476868632 hasConcept C203014093 @default.
• W2476868632 hasConcept C2522874641 @default.

• next