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- W2476885105 abstract "Background/aims:: To study the frequency of 17p(p53) loss of heterozygosity (LOH) and increased 4N and /or aneuploidy in gastric adenocarcinoma and chronic atrophic gastritis(CAG ). We reported 17p(p53)LOH, may be an important prognostic factor in early gastric carcinoma. Methods: We have used the endoscopic biopsies from patients for DNA extraction and for flow cytometric abnormalities. The PCR was carried out by using a set of primers containing codon 72 of exon 4 of the p53 gene. Amplified fragments were subjected to restriction enzyme BstUI for detecting 17p(p53) LOH. Biopsy specimens were processed for flow cytometry. Ki-67/DNA content was used to see increased 4N or aneuploid fractions. Results: 17p(p53)LOH was observed in (21 of 41) 51.21% of gastric adenocarcinomas and in (13 of 43) 30.23% chronic atrophic gastritis(CAG). Similarly, increased 4N and/or aneuploidy was detected in (18 of 41) 43.9% of adenocarcinomas and in (11 of 43) 25.58% of CAG. Conclusions: 17p(p53) LOH may be a predictor of progression in gastric carcinoma and role of neoplasm processing that can be combined with a panel of other validated biomarkers for risk assessment such as family history, biochemical and histopathological markers." @default.
- W2476885105 created "2016-08-23" @default.
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- W2476885105 date "2007-01-01" @default.
- W2476885105 modified "2023-09-24" @default.
- W2476885105 title "Predictor of progression in gastric carcinoma: 17p(p53) loss of heterozygosity displays an increased risk for cancer progression" @default.
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- W2476885105 doi "https://doi.org/10.5580/16af" @default.
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