Matches in SemOpenAlex for { <https://semopenalex.org/work/W2477035072> ?p ?o ?g. }
- W2477035072 endingPage "185" @default.
- W2477035072 startingPage "169" @default.
- W2477035072 abstract "The neurochemical alterations underlying the cognitive and behavioral symptoms that constitute the clinical picture of Alzheimer’s disease (AD), which should be reproduced by an animal model of the disease, are briefly described. The ideal animal model of AD and related dementias should include β-amyloid deposition evolving in senile plaques (SP), tau protein hyperphosphorylation resulting in neurofibrillary tangles (NFT), an inflammatory reaction, and the degeneration of the forebrain cholinergic neurons with the ensuing cholinergic hypofunction. However, since the understanding of AD pathogenesis has grown step by step during 30 years of research, simpler models, only reproducing one or a few neurochemical changes, have been gradually developed beginning from the lesion of the cholinergic nuclei and ending with transgenic mice developing SP and NFT. The partial models still maintain their usefulness for understanding the different pathogenetic mechanisms and for developing new drugs. The animal models are validated by the demonstration, through appropriate and specific methods, that they show the neurochemical changes that they are meant to reproduce. The methods are mentioned and briefly described in this chapter, and evidence of their validity is given by quoting significant papers in which they have been used." @default.
- W2477035072 created "2016-08-23" @default.
- W2477035072 creator A5041471464 @default.
- W2477035072 creator A5053047266 @default.
- W2477035072 date "2010-10-22" @default.
- W2477035072 modified "2023-10-07" @default.
- W2477035072 title "Validation of Animal Models of Dementia: Neurochemical Aspects" @default.
- W2477035072 cites W1480786153 @default.
- W2477035072 cites W1528219518 @default.
- W2477035072 cites W1550759106 @default.
- W2477035072 cites W1611407165 @default.
- W2477035072 cites W1693283493 @default.
- W2477035072 cites W1963775899 @default.
- W2477035072 cites W1966768311 @default.
- W2477035072 cites W1967464880 @default.
- W2477035072 cites W1969768548 @default.
- W2477035072 cites W1971048984 @default.
- W2477035072 cites W1972718612 @default.
- W2477035072 cites W1975506293 @default.
- W2477035072 cites W1976618296 @default.
- W2477035072 cites W1977002082 @default.
- W2477035072 cites W1980767889 @default.
- W2477035072 cites W1982064952 @default.
- W2477035072 cites W1984160734 @default.
- W2477035072 cites W1984482388 @default.
- W2477035072 cites W1992953921 @default.
- W2477035072 cites W1994058950 @default.
- W2477035072 cites W1994067502 @default.
- W2477035072 cites W1994298686 @default.
- W2477035072 cites W1996583908 @default.
- W2477035072 cites W1996909837 @default.
- W2477035072 cites W1999700051 @default.
- W2477035072 cites W2000526690 @default.
- W2477035072 cites W2011353108 @default.
- W2477035072 cites W2013706950 @default.
- W2477035072 cites W2015163544 @default.
- W2477035072 cites W2015678036 @default.
- W2477035072 cites W2019087169 @default.
- W2477035072 cites W2019264979 @default.
- W2477035072 cites W2022532247 @default.
- W2477035072 cites W2023187813 @default.
- W2477035072 cites W2024592322 @default.
- W2477035072 cites W2026576926 @default.
- W2477035072 cites W2027971714 @default.
- W2477035072 cites W2032009532 @default.
- W2477035072 cites W2032365749 @default.
- W2477035072 cites W2034286717 @default.
- W2477035072 cites W2034741269 @default.
- W2477035072 cites W2034988775 @default.
- W2477035072 cites W2035189475 @default.
- W2477035072 cites W2035792930 @default.
- W2477035072 cites W2036642860 @default.
- W2477035072 cites W2038072430 @default.
- W2477035072 cites W2039194350 @default.
- W2477035072 cites W2039198097 @default.
- W2477035072 cites W2040949523 @default.
- W2477035072 cites W2041730776 @default.
- W2477035072 cites W2043661712 @default.
- W2477035072 cites W2044974101 @default.
- W2477035072 cites W2046202110 @default.
- W2477035072 cites W2049301406 @default.
- W2477035072 cites W2059360174 @default.
- W2477035072 cites W2059721162 @default.
- W2477035072 cites W2062550706 @default.
- W2477035072 cites W2062772621 @default.
- W2477035072 cites W2068477037 @default.
- W2477035072 cites W2073724760 @default.
- W2477035072 cites W2074274825 @default.
- W2477035072 cites W2075836513 @default.
- W2477035072 cites W2076467891 @default.
- W2477035072 cites W2076862522 @default.
- W2477035072 cites W2077859295 @default.
- W2477035072 cites W2078530054 @default.
- W2477035072 cites W2084043574 @default.
- W2477035072 cites W2084598728 @default.
- W2477035072 cites W2084972185 @default.
- W2477035072 cites W2088433445 @default.
- W2477035072 cites W2090778647 @default.
- W2477035072 cites W2091647878 @default.
- W2477035072 cites W2091660037 @default.
- W2477035072 cites W2092713549 @default.
- W2477035072 cites W2095873344 @default.
- W2477035072 cites W2100442322 @default.
- W2477035072 cites W2102367498 @default.
- W2477035072 cites W2102395641 @default.
- W2477035072 cites W2104227586 @default.
- W2477035072 cites W2104458545 @default.
- W2477035072 cites W2105822743 @default.
- W2477035072 cites W2107359363 @default.
- W2477035072 cites W2119125561 @default.
- W2477035072 cites W2126800086 @default.
- W2477035072 cites W2134613265 @default.
- W2477035072 cites W2135617975 @default.
- W2477035072 cites W2136160849 @default.
- W2477035072 cites W2148800099 @default.
- W2477035072 cites W2149228712 @default.
- W2477035072 cites W2152864425 @default.
- W2477035072 cites W2160033789 @default.