Matches in SemOpenAlex for { <https://semopenalex.org/work/W2477124266> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2477124266 endingPage "e42" @default.
- W2477124266 startingPage "e42" @default.
- W2477124266 abstract "Objective: Antidepressant drugs (ATD) are widely used in general medicine in France for treatment of high depressive symptoms and milder depressive manifestations. Although these drugs have marked effects on blood pressure and especially orthostatic hypotension, the respective relationships between high depressive symptoms and ATD with baroreflex sensitivity (BRS) has never been studied on a wide scale. Furthermore, this class of drugs is heterogeneous and subclasses of drugs may have different effect on blood pressure regulation. Design and method: We took advantage of the Paris Prospective Study III (PPS3) study, which includes 10,154 subjects from the general population, aged 50 to 75. Information on antidepressants use was obtained on a face-to-face interview with the investigator. BRS was investigated by spectral analysis of the spontaneous carotid distension rate and RR intervals using non-invasive high-resolution ultrasound carotid-echotracking. A total score superior or equal to 7 on a 13-item standardized questionnaire defined the presence of high depressive symptoms, the most recent medical prescriptions and/or medical package. The associations between high depressive symptoms, ATD use and low BRS (below the median) was quantified by logistic regression adjusted for age, sex, past history of cardiovascular disease, education, single status, smoking status, hypertension, diabetes, body mass index, resting heart rate, and physical activity. Results: Among the 9213 studied participants aged 50–75 years (38.6% of women), respectively, 5.6% and 5.2% had high-depressive symptoms and were on ATD. High depressive symptoms were not associated with low BRS even in unadjusted analysis (OR = 1.09; 95% CI: 0.91–1.30). Instead, ATD use was related to low BRS in multivariate analysis (OR = 1.27; 95% CI: 1.04–1.54). This association remains after adjusting for and matching on propensity score of receiving ATD. Exploratory analysis suggests a strong association with serotonin and norepinephrine reuptake inhibitors (OR = 1.94; 95% CI: 1.16–3.22). Conclusions: To conclude, antidepressant use but not high depressive symptoms is associated with low BRS. If confirmed, these results may bring novel insights in the mechanisms linking depressive symptoms and/or ATD use with hypertension and cardiovascular disease onset." @default.
- W2477124266 created "2016-08-23" @default.
- W2477124266 creator A5005480898 @default.
- W2477124266 creator A5007064453 @default.
- W2477124266 creator A5013213106 @default.
- W2477124266 creator A5017813723 @default.
- W2477124266 creator A5050123607 @default.
- W2477124266 creator A5052693373 @default.
- W2477124266 creator A5059515426 @default.
- W2477124266 creator A5069201621 @default.
- W2477124266 creator A5069211545 @default.
- W2477124266 creator A5084551151 @default.
- W2477124266 creator A5088444378 @default.
- W2477124266 creator A5089949559 @default.
- W2477124266 date "2016-09-01" @default.
- W2477124266 modified "2023-10-18" @default.
- W2477124266 title "[OP.4A.08] ANTIDEPRESSANT USE IS RELATED TO LOWER BAROREFLEX SENSITIVITY INDEPENDENTLY OF THE SEVERITY OF DEPRESSIVE SYMPTOMS. THE PARIS PROSPECTIVE STUDY III" @default.
- W2477124266 doi "https://doi.org/10.1097/01.hjh.0000491444.84800.0f" @default.
- W2477124266 hasPublicationYear "2016" @default.
- W2477124266 type Work @default.
- W2477124266 sameAs 2477124266 @default.
- W2477124266 citedByCount "0" @default.
- W2477124266 crossrefType "journal-article" @default.
- W2477124266 hasAuthorship W2477124266A5005480898 @default.
- W2477124266 hasAuthorship W2477124266A5007064453 @default.
- W2477124266 hasAuthorship W2477124266A5013213106 @default.
- W2477124266 hasAuthorship W2477124266A5017813723 @default.
- W2477124266 hasAuthorship W2477124266A5050123607 @default.
- W2477124266 hasAuthorship W2477124266A5052693373 @default.
- W2477124266 hasAuthorship W2477124266A5059515426 @default.
- W2477124266 hasAuthorship W2477124266A5069201621 @default.
- W2477124266 hasAuthorship W2477124266A5069211545 @default.
- W2477124266 hasAuthorship W2477124266A5084551151 @default.
- W2477124266 hasAuthorship W2477124266A5088444378 @default.
- W2477124266 hasAuthorship W2477124266A5089949559 @default.
- W2477124266 hasConcept C126322002 @default.
- W2477124266 hasConcept C134018914 @default.
- W2477124266 hasConcept C164705383 @default.
- W2477124266 hasConcept C1862650 @default.
- W2477124266 hasConcept C188816634 @default.
- W2477124266 hasConcept C191237925 @default.
- W2477124266 hasConcept C2777953023 @default.
- W2477124266 hasConcept C2779177272 @default.
- W2477124266 hasConcept C2780221984 @default.
- W2477124266 hasConcept C2781161787 @default.
- W2477124266 hasConcept C2908647359 @default.
- W2477124266 hasConcept C3019858935 @default.
- W2477124266 hasConcept C555293320 @default.
- W2477124266 hasConcept C71924100 @default.
- W2477124266 hasConcept C73787029 @default.
- W2477124266 hasConcept C84393581 @default.
- W2477124266 hasConcept C99454951 @default.
- W2477124266 hasConceptScore W2477124266C126322002 @default.
- W2477124266 hasConceptScore W2477124266C134018914 @default.
- W2477124266 hasConceptScore W2477124266C164705383 @default.
- W2477124266 hasConceptScore W2477124266C1862650 @default.
- W2477124266 hasConceptScore W2477124266C188816634 @default.
- W2477124266 hasConceptScore W2477124266C191237925 @default.
- W2477124266 hasConceptScore W2477124266C2777953023 @default.
- W2477124266 hasConceptScore W2477124266C2779177272 @default.
- W2477124266 hasConceptScore W2477124266C2780221984 @default.
- W2477124266 hasConceptScore W2477124266C2781161787 @default.
- W2477124266 hasConceptScore W2477124266C2908647359 @default.
- W2477124266 hasConceptScore W2477124266C3019858935 @default.
- W2477124266 hasConceptScore W2477124266C555293320 @default.
- W2477124266 hasConceptScore W2477124266C71924100 @default.
- W2477124266 hasConceptScore W2477124266C73787029 @default.
- W2477124266 hasConceptScore W2477124266C84393581 @default.
- W2477124266 hasConceptScore W2477124266C99454951 @default.
- W2477124266 hasIssue "Supplement 2" @default.
- W2477124266 hasLocation W24771242661 @default.
- W2477124266 hasOpenAccess W2477124266 @default.
- W2477124266 hasPrimaryLocation W24771242661 @default.
- W2477124266 hasRelatedWork W2116320226 @default.
- W2477124266 hasRelatedWork W2135965083 @default.
- W2477124266 hasRelatedWork W2147788422 @default.
- W2477124266 hasRelatedWork W2169031488 @default.
- W2477124266 hasRelatedWork W2276584358 @default.
- W2477124266 hasRelatedWork W2286377494 @default.
- W2477124266 hasRelatedWork W238900044 @default.
- W2477124266 hasRelatedWork W2417442551 @default.
- W2477124266 hasRelatedWork W2739879878 @default.
- W2477124266 hasRelatedWork W2765282022 @default.
- W2477124266 hasVolume "34" @default.
- W2477124266 isParatext "false" @default.
- W2477124266 isRetracted "false" @default.
- W2477124266 magId "2477124266" @default.
- W2477124266 workType "article" @default.