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- W2477159544 abstract "Apoptosis is a form of programmed cell death with a crucial role in health and disease in metazoans. Recent findings demonstrate the existence of an apoptotic program also in unicellular eukaryotes. Oxygen stress as well as the expression of several conserved proapoptotic genes induce the apoptotic pathway in mammalian cells and yeast cells. The dying yeast cells show diagnostic markers of apoptosis. Yeast provides a simple and powerful model for cellular ageing. Oxygen radicals are produced during mother cell-specific ageing of yeast cells. Postmitotic ageing during survival of stationary phase also is accompanied by oxidative stress. In both forms of ageing, the terminal yeast cells execute apoptosis. This may elucidate some questions about the oxygen theory of ageing in mammalian cells. The involvement of oxygen toxicity in the ageing processes of cells as widely divergent as human and yeast leads us to the proposal to use the powerful system of yeast molecular genetics to study the role of oxygen toxicity as a “public” mechanism of ageing. It has became clear through recent studies of yeast and human cells, that apoptosis is not only a mechanism to prevent ageing of a tissue by removing irreversibly damaged cells which can then be replaced by regeneration. Apoptosis is also a mechanism of death for senescent cells. Yeast cells are also an excellent system to test other current theories of ageing. Prominent among them are the theory according to which an ageing signal is produced by critically short telomeres and the theory according to which unrepaired DNA damage leads to premature ageing and apoptosis." @default.
- W2477159544 created "2016-08-23" @default.
- W2477159544 creator A5005096039 @default.
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- W2477159544 creator A5080881188 @default.
- W2477159544 creator A5084314448 @default.
- W2477159544 date "2003-11-11" @default.
- W2477159544 modified "2023-10-03" @default.
- W2477159544 title "Yeast as a model for ageing and apoptosis research" @default.
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