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- W2477166577 abstract "Objective: To determine if there are differences in 11C-Pittsburgh compound B (PIB)-positron emission tomography (11C-PIB-PET) imaging patterns between Alzheimer’s disease (AD) patients with and without cerebral cortical/subcortical microbleeds (CMBs). Background: PIB is a PET ligand that binds to β-amyloid in vivo. A previous 11C-PIB-PET study reported that patients with AD showed higher PIB uptake in the frontal lobes and lower PIB uptake in the occipital lobes than individuals with cerebral amyloid angiopathy (CAA) related hemorrhage. However, AD is frequently accompanied with CAA pathology. It is unclear whether a difference in PIB uptake exists between AD patients with and without CMBs. Methods: We recruited 31 patients with probable AD as per revised NINCDS-ADRDA criteria. 17 of 31 patients were without CMBs (12 female, 5 male; mean ± SD age, 70.9 ± 9.1 years; mean ± SD Mini-Mental Status Examination [MMSE], 17.7 ± 6.9), and 14 of 31 patients were with multiple CMBs on T2* MRI (3 female, 11 male; age, 70.4 ± 6.2 years; MMSE, 13.6 ± 6.6). We analyzed the standardized uptake value ratio (SUV-R) of 50- to 70-min of scans, divided the imaging data into 24 brain sections via a 3D stereotaxic ROI template, and compared SUV-R values between the AD patients with and without CMBs. Comparisons were via Mann-Whitney U-test, with statistical significance set at P < .05. Results: AD patients without CMBs had significantly higher average SUV-R than those with CMBs in all cerebral regions. The anterior/occipital and precentral/occipital ratio were higher in those without CBMs than those with CMBs. This difference may be reflected by the CAA pathology. Conclusions: 11C-PIB-PET imaging patterns differed between AD patients with CMBs and without CMBs. Disclosure: Dr. Hayashi has nothing to disclose. Dr. Shinoda has nothing to disclose. Dr. Yoshikura has nothing to disclose. Dr. Waza has nothing to disclose. Dr. Nishida has nothing to disclose. Dr. Asano has nothing to disclose. Dr. Kimura has nothing to disclose. Dr. Inuzuka has nothing to disclose." @default.
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- W2477166577 date "2016-04-05" @default.
- W2477166577 modified "2023-09-23" @default.
- W2477166577 title "Differences in 11C-PIB-PET Imaging Patterns Between Alzheimer’s Disease Patients with and without Cerebral Cortical/Subcortical Microbleeds (P4.021)" @default.
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