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• W2477235204 abstract "Abstract Several cellular and molecular mechanisms govern the gene expression that determines the cellular phenotype and subsequently that of the tissue, organ, and one or more body systems. There are many housekeeping and cell-type–specific genes that are dynamically expressed and repressed, generating a number of phenotypes. The overall pattern of gene expression that defines the cell type is known as the epigenotype, which is established and maintained by “epigenetic” mechanisms regardless of the genetic code. These mechanisms regulate expression of specific genes (for example, a recognizable mendelian disease) or collectively many genes and variants (for example, related to a common/complex disease) across the genome. Genomic imprinting, where genes are expressed from only one of the inherited parental alleles, represents a classical example of epigenetic gene regulation. This chapter provides an overview of the complexities of epigenetics and epigenomics specifically in relation to medical and health implications." @default.
• W2477235204 created "2016-08-23" @default.
• W2477235204 creator A5079663586 @default.
• W2477235204 date "2016-01-01" @default.
• W2477235204 modified "2023-09-26" @default.
• W2477235204 title "Epigenetics and Epigenomics in Human Health and Disease" @default.
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