Matches in SemOpenAlex for { <https://semopenalex.org/work/W2477292308> ?p ?o ?g. }
- W2477292308 endingPage "53" @default.
- W2477292308 startingPage "1" @default.
- W2477292308 abstract "Glial cells exploit calcium (Ca2+) signals to perceive the information about the activity of the nervous tissue and the tissue environment to translate this information into an array of homeostatic, signaling and defensive reactions. Astrocytes, the best studied glial cells, use several Ca2+ signaling generation pathways that include Ca2+ entry through plasma membrane, release from endoplasmic reticulum (ER) and from mitochondria. Activation of metabotropic receptors on the plasma membrane of glial cells is coupled to an enzymatic cascade in which a second messenger, InsP3 is generated thus activating intracellular Ca2+ release channels in the ER endomembrane. Astrocytes also possess store-operated Ca2+ entry and express several ligand-gated Ca2+ channels. In vivo astrocytes generate heterogeneous Ca2+ signals, which are short and frequent in distal processes, but large and relatively rare in soma. In response to neuronal activity intracellular and inter-cellular astrocytic Ca2+ waves can be produced. Astrocytic Ca2+ signals are involved in secretion, they regulate ion transport across cell membranes, and are contributing to cell morphological plasticity. Therefore, astrocytic Ca2+ signals are linked to fundamental functions of the central nervous system ranging from synaptic transmission to behavior. In oligodendrocytes, Ca2+ signals are generated by plasmalemmal Ca2+ influx, or by release from intracellular stores, or by combination of both. Microglial cells exploit Ca2+ permeable ionotropic purinergic receptors and transient receptor potential channels as well as ER Ca2+ release. In this contribution, basic morphology of glial cells, glial Ca2+ signaling toolkit, intracellular Ca2+ signals and Ca2+-regulated functions are discussed with focus on astrocytes." @default.
- W2477292308 created "2016-08-23" @default.
- W2477292308 creator A5024096995 @default.
- W2477292308 creator A5040470106 @default.
- W2477292308 creator A5049135804 @default.
- W2477292308 creator A5091093273 @default.
- W2477292308 date "2021-01-01" @default.
- W2477292308 modified "2023-09-25" @default.
- W2477292308 title "Calcium signaling in neuroglia" @default.
- W2477292308 cites W1485297825 @default.
- W2477292308 cites W1496438529 @default.
- W2477292308 cites W1500980879 @default.
- W2477292308 cites W1546798147 @default.
- W2477292308 cites W1563875885 @default.
- W2477292308 cites W1576543894 @default.
- W2477292308 cites W1583603147 @default.
- W2477292308 cites W1592094078 @default.
- W2477292308 cites W1594747697 @default.
- W2477292308 cites W1642571303 @default.
- W2477292308 cites W1646393677 @default.
- W2477292308 cites W1666691194 @default.
- W2477292308 cites W1815520451 @default.
- W2477292308 cites W182409224 @default.
- W2477292308 cites W1858218191 @default.
- W2477292308 cites W1861049435 @default.
- W2477292308 cites W1953584638 @default.
- W2477292308 cites W1965461706 @default.
- W2477292308 cites W1967720787 @default.
- W2477292308 cites W1968067961 @default.
- W2477292308 cites W1969914661 @default.
- W2477292308 cites W1970082704 @default.
- W2477292308 cites W1971073285 @default.
- W2477292308 cites W1971125401 @default.
- W2477292308 cites W1972077052 @default.
- W2477292308 cites W1973547785 @default.
- W2477292308 cites W1975372045 @default.
- W2477292308 cites W1975700762 @default.
- W2477292308 cites W1975880962 @default.
- W2477292308 cites W1976775990 @default.
- W2477292308 cites W1979044083 @default.
- W2477292308 cites W1979948431 @default.
- W2477292308 cites W1980090196 @default.
- W2477292308 cites W1980128229 @default.
- W2477292308 cites W1980153635 @default.
- W2477292308 cites W1980276110 @default.
- W2477292308 cites W1980746508 @default.
- W2477292308 cites W1982480910 @default.
- W2477292308 cites W1982943478 @default.
- W2477292308 cites W1984311207 @default.
- W2477292308 cites W1985262580 @default.
- W2477292308 cites W1985441433 @default.
- W2477292308 cites W1985757780 @default.
- W2477292308 cites W1990472336 @default.
- W2477292308 cites W1990978305 @default.
- W2477292308 cites W1991509237 @default.
- W2477292308 cites W1991777041 @default.
- W2477292308 cites W1998432972 @default.
- W2477292308 cites W1998820620 @default.
- W2477292308 cites W1999589115 @default.
- W2477292308 cites W1999736911 @default.
- W2477292308 cites W1999771185 @default.
- W2477292308 cites W2000215916 @default.
- W2477292308 cites W2000849772 @default.
- W2477292308 cites W2001261203 @default.
- W2477292308 cites W2001813249 @default.
- W2477292308 cites W2002962618 @default.
- W2477292308 cites W2005629604 @default.
- W2477292308 cites W2006140418 @default.
- W2477292308 cites W2006245249 @default.
- W2477292308 cites W2007553871 @default.
- W2477292308 cites W201144505 @default.
- W2477292308 cites W2013950297 @default.
- W2477292308 cites W2016548049 @default.
- W2477292308 cites W2016814488 @default.
- W2477292308 cites W2018039955 @default.
- W2477292308 cites W2018323716 @default.
- W2477292308 cites W201833149 @default.
- W2477292308 cites W2022040353 @default.
- W2477292308 cites W2022867171 @default.
- W2477292308 cites W2023332232 @default.
- W2477292308 cites W2024952182 @default.
- W2477292308 cites W2025097191 @default.
- W2477292308 cites W2026029720 @default.
- W2477292308 cites W2026154459 @default.
- W2477292308 cites W2026602510 @default.
- W2477292308 cites W2026688064 @default.
- W2477292308 cites W2026708997 @default.
- W2477292308 cites W2027616725 @default.
- W2477292308 cites W2027997017 @default.
- W2477292308 cites W2028036419 @default.
- W2477292308 cites W2029257586 @default.
- W2477292308 cites W2029590802 @default.
- W2477292308 cites W2030285325 @default.
- W2477292308 cites W2030323825 @default.
- W2477292308 cites W2030787126 @default.
- W2477292308 cites W2032425801 @default.
- W2477292308 cites W2033868363 @default.
- W2477292308 cites W2035841790 @default.