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• W2477363729 abstract "Background: One of the best characterized apoptosis triggering systems is the CD95/Fas/APO-1 pathway. Aim of the study was to evaluate the serum sFas levels in cervical neoplasia and localized cervical cancer patients and examines its role as a discriminator between precancerous and cancerous cervical lesion. Methods: A case control study was conducted in Department of Obstetrics & Gynaecology, in collaboration with Pathology, CSM Medical University, Lucknow. 5ml venous blood samples were drawn into sterile vials, prior to treatment being administered. sFas levels were measured with an enzyme linked immunosorbent assay in histopathological proven 45 cases of Cervical Intraepithelial Neoplasia (CIN I, II and III), 30 cervical cancer patients (FIGO Stage I and II) and 30 cervical cytology negative healthy volunteers (Pap Smear). Results: In the present study we observed a significant positive correlation between sFas levels of healthy controls, CIN I, CIN II, CIN III and early invasive localized cancer patients (stage I and II) (p<0.001). It was observed that the three stages of precancer, and stage I and II of cervical cancer although had small difference in their mean sFas levels yet, can be precisely discriminated on the basis of mean sFas level alone. Risk classification matrix obtained using the discriminate function analysis, showed that sFas levels in plasma of patients with CIN I, II and III could helped in better predicting the risk of developing invasive cervical cancer in individual patient. sFas level was able to validate about 98% of cases correctly. Conclusions: This study demonstrates that sFas levels could be used as a discriminator between precancerous and cancerous cervical lesion. The clear discrimination between precancerous and cancerous cervical lesions by sFas can be used in quantification of the risk to have a better understanding of natural history of disease." @default.
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• W2477363729 date "2012-01-01" @default.
• W2477363729 modified "2023-09-26" @default.
• W2477363729 title "Serum Soluble Fas (sFas) levels might be a discriminator between precancerous and Cancerous Cervical lesion in North Indian Population- A case control study" @default.
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