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- W2477388163 abstract "Involvement of the central nervous system (CNS) by metastatic malignant disease has become progressively more important. It is now clear that dramatically successful palliative-treatment of malignancy is a necessary precedent of the growing importance of the CNS in metastatic cancer. One of the first malignant diseases where this became a major clinical and therapeutic problem was acute leukaemia in children. Among the first 150 patients with acute leukaemia admitted to the newly-created Clinical Center of the National Institutes of Health between July 1953 and 1958, 25 patients (16.7 per cent) were described who had CNS signs and symptoms, whereas we could identify only 100 patients with similar findings reported in the world’s literature prior to 1959 (Shaw et al. 1960). Thus, less than a decade after the discovery of the first significant palliative treatment for childhood acute leukaemia the syndrome associated with diffuse meningeal leukaemia was described and its control and the palliative therapy with intrathecal therapy described. Subsequently the successful management of diffuse histiocytic lymphoma has now been shown to be complicated again by a high frequency of residual and recurrent disease primarily in the CNS. Similar findings are appearing progressively in patients with oat cell cancer of the lung, metastatic breast cancer and soft tissue sarcoma. Thus it is reasonable to conclude that while diffuse metastatic disease can involve the CNS as a part of the diffuse metastatic process, once effective therapy is discovered for specific malignancies, then the CNS cancer becomes highly significant clinically." @default.
- W2477388163 created "2016-08-23" @default.
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- W2477388163 date "1979-01-01" @default.
- W2477388163 modified "2023-09-23" @default.
- W2477388163 title "The Clinical Pharmacology of New Agents related to the Treatment of Diffuse Meningeal Carcinomatosis" @default.
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- W2477388163 doi "https://doi.org/10.1007/978-1-349-04285-2_35" @default.
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