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- W2477409058 abstract "The analysis of the relation between the molecular structure of drugs and their biological effects focuses on the structural characteristics of the drug that are recognized by receptors and on the possible molecular mechanisms that can lead to the tissue response. The basic assumption is that the interaction between drugs and receptors is dependent on the same molecular parameters that determine chemical interactions and reactions (1). On that basis, a description of drug-receptor interactions and mechanisms should follow the formal patterns of chemistry. Clearly the special parameters of biomolecular interactions, such as size and complexity of environment, determine a special class for these phenomena. Theoretical considerations as well as documented success in the study of biological interactions indicate, however, that these complex phenomena can be decomposed into physically meaningful steps that are amenable to analysis by methods of theoretical and quantum chemistry. A schematic representation of one possible form of" @default.
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- W2477409058 date "1979-11-28" @default.
- W2477409058 modified "2023-09-25" @default.
- W2477409058 title "The Molecular Basis of Structure-Activity Relationships: Quantum Chemical Recognition Mechanisms in Drug-Receptor Interactions" @default.
- W2477409058 doi "https://doi.org/10.1021/bk-1979-0112.ch007" @default.
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