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- W2477442482 abstract "Hybridoma lines secreting monoclonal antibodies (McAbs) against hGH were established, and specificity studies of antibodies from three such lines performed. One of the McAbs cross reacts with hCS whereas the others do not, indicating that the different McAbs are directed against at least two distinct antigenic determinants. The cross reacting McAb also possesses the highest relative affinity for hGH. These antibodies were used to compare pituitary hGH and biosynthetic hGH produced in bacteria by means of recombinant-DNA, technique. In an indirect competitive ELISA. and in an indirect passive hemagglutination inhibition assay none of the McAbs could discriminate biosynthetic from pituitary hGH. This provides evidence for idential amino acid sequence and conformation in the two hormone preparations within at least two antigenic regions." @default.
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- W2477442482 date "1982-01-01" @default.
- W2477442482 modified "2023-09-23" @default.
- W2477442482 title "Monoclonal Antibodies Against Human Growth Hormone" @default.
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- W2477442482 doi "https://doi.org/10.1016/b978-0-08-027988-6.50194-4" @default.
- W2477442482 hasPublicationYear "1982" @default.
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