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- W2477446530 abstract "In treatment of metal poisonings, the top priorities should be prevention of further uptake, decreased absorption from the gastrointestinal tract, and general supportive therapy focusing on the maintenance of respiration, circulation, water and electrolyte balance, and control of cerebral function. Elimination of the absorbed poison can be facilitated by diuresis, hemodialysis, or exchange transfusion. Chelating agents counteract the effects of an absorbed toxic metal by displacing the metal from its receptor site into urine or a tissue where it cannot exert toxic effects. Chelation therapy is indicated in the treatment of metal poisonings, metal storage diseases, and to aid the elimination of some radionuclides. Chelators may also have toxic effects, for example, by depletion of essential metals or by the reallocation of toxic metals to other vulnerable tissues. Use and misuse of chelators are discussed in this chapter. Dimercaprol (BAL), the classical but now a rather outdated chelator with high toxicity, competes with protein thiol groups for arsenic and some other metals. Today its less toxic analogs Dimaval (DMPS) and Succimer (DMSA) are used in the treatment of intoxications by arsenic, mercury, bismuth, and lead. The previous use of intravenous calcium EDTA, may redistribute lead to the brain after acute or chronic poisoning, and is therefore not recommended. Due to its serious side effects, the use of EDTA in atherosclerotic diseases is contraindicated. Penicillamine and trientine have proven to be effective in the treatment of copper accumulation and in the management of Wilson’s disease. Deferoxamine is the treatment of choice in acute iron poisoning. It can also be used in the treatment of transfusional siderosis, preferably in combination with deferiprone or deferasirox, the new oral agents that can mobilize intracellular iron from liver and heart. Derivatives of DTPA as aerosol have been used to decrease the lung deposits of inhaled plutonium." @default.
- W2477446530 created "2016-08-23" @default.
- W2477446530 creator A5022666353 @default.
- W2477446530 creator A5080871218 @default.
- W2477446530 date "2016-01-01" @default.
- W2477446530 modified "2023-10-16" @default.
- W2477446530 title "Guidance for Clinical Treatment of Metal Poisonings—Use and Misuse of Chelating Agents" @default.
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