Matches in SemOpenAlex for { <https://semopenalex.org/work/W2477552010> ?p ?o ?g. }
- W2477552010 endingPage "237" @default.
- W2477552010 startingPage "223" @default.
- W2477552010 abstract "Tumor-stroma interactions are of great importance not only for the development and progression of primary prostate carcinoma but probably also for the establishment of metastasis. Fibroblasts are an important stromal cell type encountered by metastatic tumor cells at different sites. In previous investigations, we had found that media conditioned by three metastatic prostate cancer cell lines (LNCaP, PC-3, and DU-145) induced cultured nonprostatic fibroblasts to proliferate or to express matrix-metalloproteinase-1 considered important for tumor invasion. Fibroblast-conditioned media in turn stimulate proliferation of DU-145 cells and migration of PC-3 cells. Both tumor cells and fibroblasts secrete VEGF suggesting that not only metastatic but also stromal cells at metastatic sites contribute to the vascularization of metastasis necessary for continuous growth. In order to better understand the reciprocal tumor-stroma cross-talk in molecular terms we used the mRNA extracted from stimulated and unstimulated neoplastic and fibroblastic stromal cells for cDNA array hybridization using Affymetrix chips. The three prostate cell lines influenced the fibroblasts nearly in the same manner. In particular proteins involved in cell adhesion, cell-cell contact, and cell cycle regulation were downregulated in stimulated fibroblasts. In contrast, fibroblasts affected every prostate cancer cell line in different ways, which may be because of the different origin of the metastatic prostate cancer cell lines." @default.
- W2477552010 created "2016-08-23" @default.
- W2477552010 creator A5034116088 @default.
- W2477552010 creator A5038809625 @default.
- W2477552010 creator A5069024377 @default.
- W2477552010 creator A5073201586 @default.
- W2477552010 date "2007-01-01" @default.
- W2477552010 modified "2023-09-26" @default.
- W2477552010 title "Tumor-Stroma Interactions of Metastatic Prostate Cancer Cell Lines" @default.
- W2477552010 cites W102043319 @default.
- W2477552010 cites W1656339735 @default.
- W2477552010 cites W1740737174 @default.
- W2477552010 cites W1794612623 @default.
- W2477552010 cites W1896753574 @default.
- W2477552010 cites W1971366079 @default.
- W2477552010 cites W1975506307 @default.
- W2477552010 cites W1975577875 @default.
- W2477552010 cites W1979869077 @default.
- W2477552010 cites W1981682439 @default.
- W2477552010 cites W1986373643 @default.
- W2477552010 cites W1986880110 @default.
- W2477552010 cites W1991842536 @default.
- W2477552010 cites W1993040599 @default.
- W2477552010 cites W1993635973 @default.
- W2477552010 cites W1995487355 @default.
- W2477552010 cites W1999309742 @default.
- W2477552010 cites W2001148099 @default.
- W2477552010 cites W2003681147 @default.
- W2477552010 cites W2004848487 @default.
- W2477552010 cites W2008892444 @default.
- W2477552010 cites W2009269691 @default.
- W2477552010 cites W2010069724 @default.
- W2477552010 cites W2012661940 @default.
- W2477552010 cites W2013625937 @default.
- W2477552010 cites W2015293591 @default.
- W2477552010 cites W2021868064 @default.
- W2477552010 cites W2024943689 @default.
- W2477552010 cites W2031848573 @default.
- W2477552010 cites W2036633891 @default.
- W2477552010 cites W2044828823 @default.
- W2477552010 cites W2047057038 @default.
- W2477552010 cites W2047234875 @default.
- W2477552010 cites W2055069711 @default.
- W2477552010 cites W2055399016 @default.
- W2477552010 cites W2061279269 @default.
- W2477552010 cites W2064117760 @default.
- W2477552010 cites W2066570340 @default.
- W2477552010 cites W2070852249 @default.
- W2477552010 cites W2073790698 @default.
- W2477552010 cites W2074930762 @default.
- W2477552010 cites W2076080521 @default.
- W2477552010 cites W2082787262 @default.
- W2477552010 cites W2084591798 @default.
- W2477552010 cites W2085712587 @default.
- W2477552010 cites W2086152285 @default.
- W2477552010 cites W2086457971 @default.
- W2477552010 cites W2089290731 @default.
- W2477552010 cites W2096287539 @default.
- W2477552010 cites W2098305726 @default.
- W2477552010 cites W2120435603 @default.
- W2477552010 cites W2132184673 @default.
- W2477552010 cites W2133931360 @default.
- W2477552010 cites W2137330819 @default.
- W2477552010 cites W2139241763 @default.
- W2477552010 cites W2139565067 @default.
- W2477552010 cites W2145231286 @default.
- W2477552010 cites W2146038288 @default.
- W2477552010 cites W2160042168 @default.
- W2477552010 cites W2160579552 @default.
- W2477552010 cites W2161103103 @default.
- W2477552010 cites W2161810908 @default.
- W2477552010 cites W2169632378 @default.
- W2477552010 cites W2417212197 @default.
- W2477552010 cites W2624052283 @default.
- W2477552010 cites W4252109890 @default.
- W2477552010 cites W4252110563 @default.
- W2477552010 cites W4254912248 @default.
- W2477552010 cites W72308992 @default.
- W2477552010 doi "https://doi.org/10.1007/978-1-59745-304-2_14" @default.
- W2477552010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18220234" @default.
- W2477552010 hasPublicationYear "2007" @default.
- W2477552010 type Work @default.
- W2477552010 sameAs 2477552010 @default.
- W2477552010 citedByCount "8" @default.
- W2477552010 countsByYear W24775520102012 @default.
- W2477552010 countsByYear W24775520102016 @default.
- W2477552010 countsByYear W24775520102020 @default.
- W2477552010 crossrefType "book-chapter" @default.
- W2477552010 hasAuthorship W2477552010A5034116088 @default.
- W2477552010 hasAuthorship W2477552010A5038809625 @default.
- W2477552010 hasAuthorship W2477552010A5069024377 @default.
- W2477552010 hasAuthorship W2477552010A5073201586 @default.
- W2477552010 hasConcept C121608353 @default.
- W2477552010 hasConcept C142724271 @default.
- W2477552010 hasConcept C1491633281 @default.
- W2477552010 hasConcept C16930146 @default.
- W2477552010 hasConcept C203014093 @default.
- W2477552010 hasConcept C204232928 @default.