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- W2477639565 abstract "Parathyroid Hormone-Related Protein (PTHrP) is regarded as a prototypical polyhormone encompassing several distinct, functional regions that mediate unique and independent biological processes under highly specific circumstances. Initial analyses of the actions of PTHrP were considered only in terms of its interaction with the type 1 PTH receptor. Studies now indicate that this peptide can influence fetal development via signaling pathways that extend beyond conventional secretion and cell surface receptor activation. Thus, PTHrP action must be considered in terms of direct effects at the level of the nucleus/nucleolus. Therefore, it is essential to understand the mechanism whereby PTHrP translocates to the nucleus and influences cell function through its intracrine actions. Over the past two decades, other molecules that bind to cell surface receptors— such as insulin, growth hormone, prolactin, somatostatin, nerve growth factor, and fibroblast growth factors have been proposed to influence cellular function in a dual manner by : (1) Binding to cell surface receptors in their classic endocrine/paracrine mechanism of action. (2) Targeting of the protein to the nucleus and/or nucleolus of the cell in an intracrine signaling pathway. Impairment of this process may critically alter the course of normal cell biology. This has important implications for appreciation of PTHrP as a signaling molecule in development and as an oncoprotein during the progressive stages of neoplasia." @default.
- W2477639565 created "2016-08-23" @default.
- W2477639565 creator A5014803853 @default.
- W2477639565 creator A5039697461 @default.
- W2477639565 date "2001-01-01" @default.
- W2477639565 modified "2023-09-27" @default.
- W2477639565 title "Nuclear Actions of PTHrP" @default.
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- W2477639565 doi "https://doi.org/10.1016/b978-012098651-4/50008-0" @default.
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