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- W2477673016 abstract "bythe rabbit aortic strip (RAS)attimes concurrent withitsvasorelaxation. Suchan assay isan important test oftheprodrug hypothesis whereitispostulated thatglyceryl trinitrate (GTN)isbiotransformed to nitric oxide (NO),theactive species thatinitiates vascular smoothmusclerelaxation. To testsucha hypothesis, we proposethat a sample ofsmoothmuscle, poorly responsive toGTN, yetsensitive tothe effects ofNO couldbeusedtodetect RAS production ofNO fromGTN. 2 Muscle strips ofrabbit taenia coli(RTCS)andRAS inclose apposition, were mountedintissue baths, andmuscle relaxation was recorded withisometric force transducers. Tissues were submaximally precontracted with30-35mMK+ depolarizing solution andexposed toincreasing concentrations of GTN (0.1nM-l0IM). 3 EC25forGTN-induced relaxation ofRTCSinthepresenceofRAS was significantly decreased to thatforRTCSintheabsence ofRAS(5.9 ± 3.0X 10-8 M and5.5 ± 3.7X 10-6 M, respectively). Mean maximal levels ofGTN-induced relaxation ofsimilarly precontracted RTCSalsodiffered inthepresence andabsence ofRAS,viz., 80.8 ± 2.1%and29.8 ± 8.3%respectively. 4 RTCSwas found torelax upon administration ofNO gasbubbled through theincubation medium. Analysis oftissue bathmediumrevealed thattheNO concentration towhichRTCS was exposed attained a maximumof33nM. Relaxation ofRTCS byNO gas was inhibited by 1 gM reduced haemoglobin. 5 ForGTN-incubation withintestinal andvascular smooth muscle preparations, NO formation was greater withRAScompared toRTCS.Thus, inthetwo-issue bioassay, theRAS was thepredominant sourceofNO formation fromGTN. 6 Reduced deoxyhaemoglobin (1pM), a potentextracellular NO scavenger,was found todecrease the augmented GTN-induced relaxation intheRTCS-RASsandwich preparation from17.3 ± 1.8%to 8.0 ± 0.8%.Theaugmented RTCS responsewas restored upon washout andsubsequent addition of GTN,intheabsence ofreduced Hb. 7 Thesedataindicate thatnitric oxide or a closely related NO-donorisproduced byvascular biotransformation" @default.
- W2477673016 created "2016-08-23" @default.
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- W2477673016 date "1994-01-01" @default.
- W2477673016 modified "2023-09-25" @default.
- W2477673016 title "Nitric oxide formation fromglyceryl trinitrate -byrabbit aortic strip: detection byrabbit taenia coli concurrentwith vasorelaxation" @default.
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