Matches in SemOpenAlex for { <https://semopenalex.org/work/W2477731609> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2477731609 endingPage "409" @default.
- W2477731609 startingPage "405" @default.
- W2477731609 abstract "The purpose of the present paper was to study the pharmacokinetic characteristics of homoplantaginin, a major active ingredient of Salvia plebeia R.Br. In this study, the effective partition coefficient, in situ absorption in rat intestinal segments and in vitro biotransformation of homoplantaginin by rat intestinal bacteria were determined. In addition, homoplantaginin was administered to rats by intravenous, peritoneal injection and oral administration. The concentrations of homoplantaginin and hispidulin, a metabolite of homoplantaginin, were determined by a validated highperformance liquid chromatographic (HPLC) assay. After intravenous, peritoneal injection, the concentration of hispidulin could not be determined. In contrast, after oral administration, hispidulin and homoplantaginin were simultaneous quantified, homoplantaginin was rapidly absorbed (Tmax=16.00±8.94min), reaching a mean Cmax between 0.77 and 1.27nmol/mL. The absolute oral bioavailability was calculated to be only 0.75%, and the area under curve (AUC) of hispidulin was about 5.4 times than that of homoplantaginin. The poor oral bioavailability may be attributed to the biotransformation of homoplantaginin by rat intestinal bacteria." @default.
- W2477731609 created "2016-08-23" @default.
- W2477731609 creator A5001674066 @default.
- W2477731609 creator A5032569977 @default.
- W2477731609 creator A5032853646 @default.
- W2477731609 creator A5070725064 @default.
- W2477731609 creator A5078707687 @default.
- W2477731609 creator A5082069594 @default.
- W2477731609 creator A5082857859 @default.
- W2477731609 creator A5084964328 @default.
- W2477731609 date "2016-09-01" @default.
- W2477731609 modified "2023-09-27" @default.
- W2477731609 title "Pharmacokinetics of homoplantaginin in rats following intravenous, peritoneal injection and oral administration" @default.
- W2477731609 cites W1964897058 @default.
- W2477731609 cites W1974083845 @default.
- W2477731609 cites W1996589276 @default.
- W2477731609 cites W1999554610 @default.
- W2477731609 cites W2004582958 @default.
- W2477731609 cites W2005392863 @default.
- W2477731609 cites W2028633072 @default.
- W2477731609 cites W2055037481 @default.
- W2477731609 cites W2059721261 @default.
- W2477731609 cites W2104185828 @default.
- W2477731609 cites W2163270725 @default.
- W2477731609 cites W2172455663 @default.
- W2477731609 cites W2222524673 @default.
- W2477731609 cites W967553177 @default.
- W2477731609 doi "https://doi.org/10.1016/j.jpba.2016.07.034" @default.
- W2477731609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27474945" @default.
- W2477731609 hasPublicationYear "2016" @default.
- W2477731609 type Work @default.
- W2477731609 sameAs 2477731609 @default.
- W2477731609 citedByCount "10" @default.
- W2477731609 countsByYear W24777316092018 @default.
- W2477731609 countsByYear W24777316092019 @default.
- W2477731609 countsByYear W24777316092020 @default.
- W2477731609 countsByYear W24777316092021 @default.
- W2477731609 countsByYear W24777316092022 @default.
- W2477731609 countsByYear W24777316092023 @default.
- W2477731609 crossrefType "journal-article" @default.
- W2477731609 hasAuthorship W2477731609A5001674066 @default.
- W2477731609 hasAuthorship W2477731609A5032569977 @default.
- W2477731609 hasAuthorship W2477731609A5032853646 @default.
- W2477731609 hasAuthorship W2477731609A5070725064 @default.
- W2477731609 hasAuthorship W2477731609A5078707687 @default.
- W2477731609 hasAuthorship W2477731609A5082069594 @default.
- W2477731609 hasAuthorship W2477731609A5082857859 @default.
- W2477731609 hasAuthorship W2477731609A5084964328 @default.
- W2477731609 hasConcept C112705442 @default.
- W2477731609 hasConcept C149151106 @default.
- W2477731609 hasConcept C179998833 @default.
- W2477731609 hasConcept C181389837 @default.
- W2477731609 hasConcept C185592680 @default.
- W2477731609 hasConcept C22979827 @default.
- W2477731609 hasConcept C2777056448 @default.
- W2477731609 hasConcept C2777477808 @default.
- W2477731609 hasConcept C43617362 @default.
- W2477731609 hasConcept C55493867 @default.
- W2477731609 hasConcept C71924100 @default.
- W2477731609 hasConcept C98274493 @default.
- W2477731609 hasConceptScore W2477731609C112705442 @default.
- W2477731609 hasConceptScore W2477731609C149151106 @default.
- W2477731609 hasConceptScore W2477731609C179998833 @default.
- W2477731609 hasConceptScore W2477731609C181389837 @default.
- W2477731609 hasConceptScore W2477731609C185592680 @default.
- W2477731609 hasConceptScore W2477731609C22979827 @default.
- W2477731609 hasConceptScore W2477731609C2777056448 @default.
- W2477731609 hasConceptScore W2477731609C2777477808 @default.
- W2477731609 hasConceptScore W2477731609C43617362 @default.
- W2477731609 hasConceptScore W2477731609C55493867 @default.
- W2477731609 hasConceptScore W2477731609C71924100 @default.
- W2477731609 hasConceptScore W2477731609C98274493 @default.
- W2477731609 hasLocation W24777316091 @default.
- W2477731609 hasLocation W24777316092 @default.
- W2477731609 hasOpenAccess W2477731609 @default.
- W2477731609 hasPrimaryLocation W24777316091 @default.
- W2477731609 hasRelatedWork W105896576 @default.
- W2477731609 hasRelatedWork W2028112905 @default.
- W2477731609 hasRelatedWork W2035555935 @default.
- W2477731609 hasRelatedWork W2056938528 @default.
- W2477731609 hasRelatedWork W2069936009 @default.
- W2477731609 hasRelatedWork W2145831802 @default.
- W2477731609 hasRelatedWork W2148177218 @default.
- W2477731609 hasRelatedWork W2359419803 @default.
- W2477731609 hasRelatedWork W2900112275 @default.
- W2477731609 hasRelatedWork W3120625362 @default.
- W2477731609 hasVolume "129" @default.
- W2477731609 isParatext "false" @default.
- W2477731609 isRetracted "false" @default.
- W2477731609 magId "2477731609" @default.
- W2477731609 workType "article" @default.