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- W2477748082 abstract "The effect of 1-β-D-arabinofuranosyl-E-5-(2-bromovinyl) uracil (BV-araU), a new antiviral drug, on Epstein-Barr virus (EBV) was studied. BV-araU effectively inhibits EBV replication both in superinfected Raji cells and in virus-producer P3HR-1 cells, as determined by density gradient centrifugation, in situ cytohybridization with an EBV DNA probe and by cRNA-DNA hybridization. The ED50 for virus replication and ID50 for cell growth were 0.2 6 and 390 um, respectively. The therapeutic index (ID50/ED50) was 1500. Kinetic analysis of reversibility of EBV DNA replication after removal of the drug indicated that BV-araU has more a prolonged inhibitory effect than ACV. These results indicate that BV-araU is a potent anti-EBV drug." @default.
- W2477748082 created "2016-08-23" @default.
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- W2477748082 date "1987-01-01" @default.
- W2477748082 modified "2023-09-22" @default.
- W2477748082 title "Inhibition of Epstein-Barr Virus Replication by 1-β-d-Arabinofuranosyl-E-5-(2-Bromovinyl) Uracil in Vitro" @default.
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- W2477748082 doi "https://doi.org/10.1007/978-1-4612-4590-2_106" @default.
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