FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2477767583> ?p ?o ?g. }

• W2477767583 abstract "Abstract Radiation therapy is commonly used to treat cancer patients but exhibits adverse effects, including insufficiency fractures and bone loss. Epigenetic regulation plays an important role in osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Here, we reported local bone changes after single-dose exposure to 137 C S irradiation in rats. Femur bone mineral density (BMD) and trabecular bone volume in the tibia were significantly decreased at 12 weeks after irradiation. Micro-CT results showed that tBMD, Tb.h and Tb.N were also significantly reduced at 12 weeks after irradiation exposure. ALP-positive OB.S/BS was decreased by 42.3% at 2 weeks after irradiation and was decreased by 50.8% at 12 weeks after exposure. In contrast to the decreased expression of Runx2 and BMP2, we found EZH2 expression was significantly increased at 2 weeks after single-dose 137 C S irradiation in BMSCs. Together, our results demonstrated that single-dose 137 C S irradiation induces BMD loss and the deterioration of bone microarchitecture in the rat skeleton. Furthermore, EZH2 expression increased and osteoblastogenesis decreased after irradiation. The underlying mechanisms warrant further investigation." @default.
• W2477767583 created "2016-08-23" @default.
• W2477767583 creator A5002989556 @default.
• W2477767583 creator A5018516855 @default.
• W2477767583 creator A5020438554 @default.
• W2477767583 creator A5022028615 @default.
• W2477767583 creator A5037305252 @default.
• W2477767583 creator A5077906577 @default.
• W2477767583 creator A5079696118 @default.
• W2477767583 date "2016-08-08" @default.
• W2477767583 modified "2023-10-17" @default.
• W2477767583 title "Increased EZH2 and decreased osteoblastogenesis during local irradiation-induced bone loss in rats" @default.
• W2477767583 cites W1553969934 @default.
• W2477767583 cites W1941623879 @default.
• W2477767583 cites W1964031097 @default.
• W2477767583 cites W1964046496 @default.
• W2477767583 cites W1966481454 @default.
• W2477767583 cites W1966853096 @default.
• W2477767583 cites W1974338398 @default.
• W2477767583 cites W1977734238 @default.
• W2477767583 cites W1982187648 @default.
• W2477767583 cites W1984086676 @default.
• W2477767583 cites W1986964342 @default.
• W2477767583 cites W1995963733 @default.
• W2477767583 cites W1999369038 @default.
• W2477767583 cites W2031232587 @default.
• W2477767583 cites W2045140392 @default.
• W2477767583 cites W2045217393 @default.
• W2477767583 cites W2055299092 @default.
• W2477767583 cites W2067129198 @default.
• W2477767583 cites W2068233870 @default.
• W2477767583 cites W2083449063 @default.
• W2477767583 cites W2100632202 @default.
• W2477767583 cites W2101587682 @default.
• W2477767583 cites W2108066709 @default.
• W2477767583 cites W2114852271 @default.
• W2477767583 cites W2122656254 @default.
• W2477767583 cites W2140146894 @default.
• W2477767583 cites W2143327145 @default.
• W2477767583 cites W2143807941 @default.
• W2477767583 cites W2144924096 @default.
• W2477767583 cites W2171860579 @default.
• W2477767583 cites W2177193863 @default.
• W2477767583 cites W2399408200 @default.
• W2477767583 cites W4239971790 @default.
• W2477767583 doi "https://doi.org/10.1038/srep31318" @default.
• W2477767583 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4976370" @default.
• W2477767583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27499068" @default.
• W2477767583 hasPublicationYear "2016" @default.
• W2477767583 type Work @default.
• W2477767583 sameAs 2477767583 @default.
• W2477767583 citedByCount "18" @default.
• W2477767583 countsByYear W24777675832017 @default.
• W2477767583 countsByYear W24777675832018 @default.
• W2477767583 countsByYear W24777675832019 @default.
• W2477767583 countsByYear W24777675832020 @default.
• W2477767583 countsByYear W24777675832021 @default.
• W2477767583 countsByYear W24777675832022 @default.
• W2477767583 countsByYear W24777675832023 @default.
• W2477767583 crossrefType "journal-article" @default.
• W2477767583 hasAuthorship W2477767583A5002989556 @default.
• W2477767583 hasAuthorship W2477767583A5018516855 @default.
• W2477767583 hasAuthorship W2477767583A5020438554 @default.
• W2477767583 hasAuthorship W2477767583A5022028615 @default.
• W2477767583 hasAuthorship W2477767583A5037305252 @default.
• W2477767583 hasAuthorship W2477767583A5077906577 @default.
• W2477767583 hasAuthorship W2477767583A5079696118 @default.
• W2477767583 hasBestOaLocation W24777675831 @default.
• W2477767583 hasConcept C105702510 @default.
• W2477767583 hasConcept C111337013 @default.
• W2477767583 hasConcept C121332964 @default.
• W2477767583 hasConcept C126322002 @default.
• W2477767583 hasConcept C134018914 @default.
• W2477767583 hasConcept C141071460 @default.
• W2477767583 hasConcept C160160445 @default.
• W2477767583 hasConcept C16685009 @default.
• W2477767583 hasConcept C181199279 @default.
• W2477767583 hasConcept C185544564 @default.
• W2477767583 hasConcept C185592680 @default.
• W2477767583 hasConcept C202751555 @default.
• W2477767583 hasConcept C2776363554 @default.
• W2477767583 hasConcept C2776541429 @default.
• W2477767583 hasConcept C2776886416 @default.
• W2477767583 hasConcept C2777236700 @default.
• W2477767583 hasConcept C2780007613 @default.
• W2477767583 hasConcept C2780554211 @default.
• W2477767583 hasConcept C30352789 @default.
• W2477767583 hasConcept C55493867 @default.
• W2477767583 hasConcept C71924100 @default.
• W2477767583 hasConceptScore W2477767583C105702510 @default.
• W2477767583 hasConceptScore W2477767583C111337013 @default.
• W2477767583 hasConceptScore W2477767583C121332964 @default.
• W2477767583 hasConceptScore W2477767583C126322002 @default.
• W2477767583 hasConceptScore W2477767583C134018914 @default.
• W2477767583 hasConceptScore W2477767583C141071460 @default.
• W2477767583 hasConceptScore W2477767583C160160445 @default.
• W2477767583 hasConceptScore W2477767583C16685009 @default.
• W2477767583 hasConceptScore W2477767583C181199279 @default.
• W2477767583 hasConceptScore W2477767583C185544564 @default.
• W2477767583 hasConceptScore W2477767583C185592680 @default.

• next