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- W2477779900 abstract "Protein diffusion in crowded intracellular fluids is a crucial determinant of many vital biochemical pathways.Frequently an anomalous diffusion of macromolecules in the cytoplasm and nucleoplasm of eukaryotic cells has been reported, and associated changes in biochemical reactions have been discussed in some detail [1].Here we show that different degrees of crowding combined with an obstructed and anomalous diffusion are key determinants of protein exchange between cytoplasm and nucleoplasm during nuclear envelope breakdown (NEB) at the onset of mitosis [2]. After NEB, a contiguous nucleo-cytoplasmic fluid is established that features an anisotropically varying anomalous diffusion of macromolecules during metaphase [3]: Diffusion appears less anomalous along the mitotic spindle axis as compared to perpendicular directions. As a consequence, the long-time diffusion of macromolecules preferentially points along the spindle axis, leading to a prolonged residence of macromolecules in the spindle region. The observed anisotropic diffusion is proposed to support the dynamic formation of a dynamic spindle matrix that controls and guides later steps in mitosis.[1] Weiss, Int. Rev. Cell Mol. Biol., 307, 383-417 (2014).[2] Schweizer, Pawar, Weiss & Maiato, J. Cell Biol. 210, 695 (2015).[3] Pawar, Donth & Weiss, Curr. Biol. 24, 1905 (2014)." @default.
- W2477779900 created "2016-08-23" @default.
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- W2477779900 date "2016-02-01" @default.
- W2477779900 modified "2023-09-29" @default.
- W2477779900 title "Anisotropic and Anomalous Diffusion in Mitotic Cells" @default.
- W2477779900 doi "https://doi.org/10.1016/j.bpj.2015.11.3187" @default.
- W2477779900 hasPublicationYear "2016" @default.
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